Gene Symbol | ACADSB |
---|---|
Entrez Gene | 36 |
Alt Symbol | 2-MEBCAD, ACAD7, SBCAD |
Species | Human |
Gene Type | protein-coding |
Description | acyl-CoA dehydrogenase, short/branched chain |
Other Description | 2-methyl branched chain acyl-CoA dehydrogenase|2-methylbutyryl-coenzyme A dehydrogenase|acyl-Coenzyme A dehydrogenase, short/branched chain|short/branched chain specific acyl-CoA dehydrogenase, mitochondrial |
Swissprots | Q5SQN6 P45954 Q96CX7 B4DQ51 |
Accessions | AAF97921 EAW49291 P45954 AK298638 BAG60813 AK314241 BAG36909 AL831821 CAD38535 BC013756 AAH13756 BC020931 BC032395 BC045723 BE875638 DA964130 HQ447278 ADQ31765 U12778 AAA74424 NM_001609 NP_001600 |
Function | Has greatest activity toward short branched chain acyl- CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl- CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent. |
Subcellular Location | Mitochondrion matrix. |
Tissue Specificity | Ubiquitous. |
Top Pathways | Fatty acid degradation, Valine, leucine and isoleucine degradation, Fatty acid metabolism |
ACADSB CRISPR/Cas9 KO Plasmid (h) - sc-406551 from Santa Cruz Biotechnology
|
||||||||
ACADSB HDR Plasmid (h) - sc-406551-HDR from Santa Cruz Biotechnology
|
||||||||
ACADSB Double Nickase Plasmid (h) - sc-406551-NIC from Santa Cruz Biotechnology
|
||||||||
ACADSB Double Nickase Plasmid (h2) - sc-406551-NIC-2 from Santa Cruz Biotechnology
|
||||||||
ACADSB CRISPR Activation Plasmid (h) - sc-406551-ACT from Santa Cruz Biotechnology
|
||||||||
ACADSB CRISPR Activation Plasmid (h2) - sc-406551-ACT-2 from Santa Cruz Biotechnology
|
||||||||
ACADSB Lentiviral Activation Particles (h) - sc-406551-LAC from Santa Cruz Biotechnology
|
||||||||
ACADSB Lentiviral Activation Particles (h2) - sc-406551-LAC-2 from Santa Cruz Biotechnology
|
||||||||
ACADSB siRNA (h) - sc-90519 from Santa Cruz Biotechnology
|
||||||||
ACADSB shRNA Plasmid (h) - sc-90519-SH from Santa Cruz Biotechnology
|
||||||||
ACADSB shRNA (h) Lentiviral Particles - sc-90519-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU041251 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN2694 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2694 from Sigma-Aldrich
|
||||||||
ACADSB siRNA (Human) - CRH0028 from Cohesion Biosciences
|
||||||||
ACADSB - MBS827820 from MyBioSource
|
||||||||
shRNA set against Human ACADSB (NM_001609.3) - SHH229950 from Creative biogene
|
||||||||
shRNA set against Human ACADSB(NM_001609.3) - SHG028033 from Creative biogene
|
||||||||
Human ACADSB siRNA - orb260530 from Biorbyt
|
||||||||
ACADSB shRNA Plasmid (Human) - CHH0028 from Cohesion Biosciences
|
||||||||
ACADSB miRNA 3'UTR clone - MiUTR1H-00092 from Creative biogene
|