CDC25C

Gene Symbol CDC25C
Entrez Gene 995
Alt Symbol CDC25, PPP1R60
Species Human
Gene Type protein-coding
Description cell division cycle 25C
Other Description M-phase inducer phosphatase 3|dual specificity phosphatase CDC25C|mitosis inducer CDC25|phosphotyrosine phosphatase|protein phosphatase 1, regulatory subunit 60
Swissprots Q9H2E9 Q9H2F1 P30307 D3DQB8 Q9H2E8 Q96PL3 Q9H168
Accessions AAL05410 AAR32098 EAW62145 EAW62146 EAW62147 EAW62148 EAW62149 EAW62150 P30307 AF086323 AF277723 AAG41885 AF277724 AAG41886 AF277725 AAG41887 AF277726 AAG41888 AF312681 AAL26835 AJ304504 CAC19192 AK097710 AK301828 BAG63273 AU098899 AU125025 AW512559 BC019089 AAH19089 DB040755 DB449713 DB516402 EU832624 ACE87715 EU832697 ACE87029 M34065 AAA35666 XM_005272145 XP_005272202 XM_005272146 XP_005272203 XM_006714739 XP_006714802 XM_011543759 XP_011542061 XM_011543760 XP_011542062 XM_011543761 XP_011542063 XM_011543762 XP_011542064 XM_011543763 XP_011542065 XM_011543764 XP_011542066 NM_001287582 NP_001274511 NM_001287583 NP_001274512 NM_001790 NP_001781 NM_022809 NP_073720
Function Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity. {ECO:0000269|PubMed:8119945}.
Subcellular Location Nucleus {ECO:0000269|PubMed:14968113, ECO:0000269|PubMed:8119945}.
Top Pathways Cell cycle, Progesterone-mediated oocyte maturation, Oocyte meiosis, MicroRNAs in cancer

Phospho-cdc25C (Ser198) Antibody - 9529 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells overexpressing full-length GST-cdc25C, untreated or treated with calyculin A #9902, using Phospho-cdc25C (Ser198) Antibody.

Phospho-cdc25C (Ser216) (63F9) Rabbit mAb - 4901 from Cell Signaling Technology

Prices $109.00, $307.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 63F9
Western Blot analysis of HT29 cells, untreated, nocodazole-treated, and lambda phosphotase-treated, using Phospho-cdc25C (Ser216) antibody (upper), and cdc25C (5H9) Rabbit Mab, #4688, (lower).

Phospho-cdc25C (Ser216) Antibody - 9528 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of wild type GST-cdc25C and mutant GST-cdc25C Ser216Ala fusion proteins, untreated or phosphorylated by Chk2, using Phospho-cdc25C (Ser216) Antibody.

Phospho-cdc25C (Thr48) (D2H3) Rabbit mAb - 12028 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2H3
Western blot analysis of extracts from HT-29 cells, asynchronous (-) or synchronized in mitosis (thymidine block, nocodazole release, mitotic shake-off; +), using Phospho-cdc25C (Thr48) (D2H3) Rabbit mAb (upper) or cdc25C (5H9) Rabbit mAb #4688 (lower).

Phospho-cdc25C (Thr48) Antibody - 9527 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western Blot analysis of HT29 cell extracts untreated, nocodazole-treated and lambda phosphotase-treated using Phospho-cdc25C (Thr48) (upper), and cdc25C (5H9) Rabbit mAb, #4688 (lower).

cdc25C (5H9) Rabbit mAb - 4688 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 5H9
Western blot analysis of extracts from HeLa, 293 and K562 cells, using cdc25C (5H9) Rabbit mAb.

Phospho-cdc25 (Ser216) 9D1 Mouse mAb - 9526 from Cell Signaling Technology

Host Mouse
Clonality Monoclonal
Clone Ser216

Phospho-cdc25C (Ser216) Antibody - 9521 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

cdc25C Antibody - 9522 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Cdc25C (F-5) - sc-55513 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdc25C (F-5): sc-55513. Western blot analysis of Cdc25C expression in K-562 whole cell lysate.

Cdc25C (H-150) - sc-5620 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Cdc25C (H-150): sc-5620. Western blot analysis of human recombinant Cdc25C fusion protein.

Cdc25C (H-6) - sc-13138 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdc25C (H-6): sc-13138. Western blot analysis of Cdc25C expression in HeLa whole cell lysate.

Cdc25C (N-19) - sc-6950 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Cdc25C (C-20) - sc-327 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Cdc25C (C-20): sc-327. Western blot analysis of Cdc25C expression in KNRK (A) and NIH/3T3 (B) whole cell lysates.

Cdc25C (TC-14) - sc-56269 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Cdc25C (TC-14): sc-56269. Western blot analysis of Cdc25C expression in HeLa (A) and K-562 (B) whole cell lysates.

p-Cdc25C (Ser 216) - sc-12354 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-Cdc25C (Ser 216)-R: sc-12354-R. Western blot analysis of Cdc25C phosphorylation in K-562 (A), PC-3 (B), Raji (C), untreated Hela (D) and nocodozole-treated Hela (E) whole cell lysates.

Anti-Cdc25C (phospho S198) antibody - ab192797 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue labeling Cdc25C (phospho S198) with ab192797 at 1/50 (left) or ab192797 preincubated with blocking peptide (right).

Anti-Cdc25C (phospho S216) antibody - ab47322 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab47322 staining human breast carcinoma tissue by IHC-P (left hand panel). The right hand panel shows staining in the presence of phospho-peptide.

Anti-Cdc25C (phospho S216) antibody - ab195955 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cdc25C (phospho S216) antibody (ab195955) at 1/500 dilutionLane 1 : Serum-treated HUVEC whole cell lysate with antigen-specific peptideLane 2 : Serum-treated HUVEC whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-Cdc25C (phospho S216) antibody [E190] - ab32051 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone E190
All lanes : Anti-Cdc25C (phospho S216) antibody [E190] (ab32051) at 1/1000 dilutionLane 1 : IR treated HeLa cell lysateLane 2 : 10 Gy IR treated (0 minutes recovery) HeLa cell lysateLane 3 : 10 Gy IR treated (30 minutes recovery) HeLa cell lysateLane 4 : 10 Gy IR treated (60 minutes recovery) HeLa cell lysateLysates/proteins at 22 µg per lane.developed using the ECL techniquePerformed under reducing conditions.

Anti-Cdc25C antibody - ab131454 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of methanol fixed HeLa cells labelling Cdc25C with ab131454 antibody at a dilution of 1/100.

Anti-Cdc25C antibody - ab84485 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab84485 at a dilution of 1/250 staining a formalin-fixed, paraffin-embedded section of human seminoma. Detection: DAB staining.

Anti-Cdc25C antibody - ab155912 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human Breast carcinoma tissue labeling Cdc25C with ab155912 at 1/250 dilution.

Anti-Cdc25C antibody - ab66235 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
ab66235, at 6µg/ml, staining Cdc25C in human salivary gland by Immunohistochemistry using formalin-fixed, paraffin-embedded tissue.

Anti-Cdc25C antibody - ab47389 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Ab47389 at 1/50 dilution staining paraffin-embedded human breast carcinoma tissue.
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