| Gene Symbol |
FBXO31
|
| Entrez Gene |
79791
|
| Alt Symbol |
FBX14, FBXO14, Fbx31, MRT45, pp2386
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
F-box protein 31
|
| Other Description |
F-box only protein 31|SCF ubiquitin ligase specificity factor|putative breast cancer tumor-suppressor
|
| Swissprots |
Q9UFV4 Q5K680 Q8WYV1 Q96D73 Q5XUX0
|
| Accessions |
EAW95400 EAW95401 EAW95402 EAW95403 EAW95404 Q5XUX0 AF318348 AAL55855 AF428140 AAQ04213 AK311122 AL117444 CAB55929 AL576585 AY736035 AAU50679 BC002985 BC012748 AAH12748 BE465371 BG718342 BI596608 BI914636 BM151642 BX106211 BX329100 DA493744 DB444853 NM_001282683 NP_001269612 NM_024735 NP_079011
|
| Function |
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. {ECO:0000269|PubMed:16357137, ECO:0000269|PubMed:19412162}.
|
| Tissue Specificity |
Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow. {ECO:0000269|PubMed:16357137}.
|