LDB1

Gene Symbol LDB1
Entrez Gene 8861
Alt Symbol CLIM2, NLI
Species Human
Gene Type protein-coding
Description LIM domain binding 1
Other Description CLIM-2|LDB-1|LIM domain-binding factor CLIM2|LIM domain-binding factor-1|LIM domain-binding protein 1|carboxy terminal LIM domain protein 2|carboxyl-terminal LIM domain-binding protein 2|hLdb1|nuclear LIM interactor
Swissprots O75479 Q9UGM4 O96010 B4DUC4 Q1EQX1 Q86U70
Accessions CAB45408 CAB45409 EAW49722 EAW49723 EAW49724 Q86U70 AB016485 BAA31991 AB250384 BAE95402 AF064491 AAC28341 AF068652 AAC77818 AK300588 BAG62286 AK308481 BC000482 AAH00482 BC009246 AAH09246 BT007054 AAP35703 CV575131 DQ890772 ABM81698 DQ893933 ABM84859 XM_005270262 XP_005270319 XM_011540315 XP_011538617 NM_001113407 NP_001106878 NM_003893 NP_003884
Function Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000305}.
Tissue Specificity Expressed in a wide range of adult tissues including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:16815859}.
Top Pathways Transcriptional misregulation in cancer

CLIM-1/2 (A-3) - sc-376030 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CLIM-1/2 (A-3): sc-376030. Western blot analysis of CLIM-1/2 expression in HeLa nuclear extract (A) and CCRF-CEM whole cell lysate (B).

CLIM-1/2 (A-6) - sc-376031 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CLIM-1/2 (A-6): sc-376031. Western blot analysis of CLIM-1/2 expression in HeLa nuclear extract (A) and CCRF-CEM whole cell lysate (B).

CLIM-1/2 (H-300) - sc-28695 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CLIM-1/2 (H-300): sc-28695. Western blot analysis of CLIM-1 and CLIM-2 expression in CCRF-CEM nuclear extract.

CLIM-1/2 (C-4) - sc-373985 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CLIM-1/2 (C-4): sc-373985. Western blot analysis of CLIM-1/2 expression in CCRF-CEM whole cell lysate.

CLIM-2 (A-4) - sc-514035 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CLIM-2 (A-4): sc-514035. Western blot analysis of CLIM-2 expression in HeLa nuclear extract (A) and CCRF-CEM whole cell lysate (B).

CLIM-2 (C-3) - sc-365245 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CLIM-2 (C-3): sc-365245. Western blot analysis of CLIM-2 expression in CCRF-CEM whole cell lysate.

CLIM-2 (F-11) - sc-365281 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CLIM-2 (F-11): sc-365281. Western blot analysis of CLIM-2 expression in CCRF-CEM whole cell lysate.

CLIM-2 (C-9) - sc-365074 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CLIM-2 (C-9): sc-365074. Western blot analysis of CLIM-2 expression in CCRF-CEM (A) and IMR-32 (B) whole cell lysates.

CLIM-2 (N-18) - sc-11198 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CLIM-2 siRNA (m): sc-35073. Western blot analysis of CLIM-2 expression in non-transfected control (A) and CLIM-2 transfected (B) NIH/3T3 cells. Blot probed with CLIM-2 (N-18): sc-11198. Actin (I-19): sc-1616 used as specificity and loading control.

CLIM-2 (T-16) - sc-11199 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CLIM-2 (T-16): sc-11199. Western blot analysis of CLIM-2 expression in HeLa nuclear extract.

CLIM-2 (L15) - sc-101089 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
CLIM-2 (L15): sc-101089. Western blot analysis of CLIM-2 expression in IMR-32 whole cell lysate.

Anti-LDB1 antibody - ab96799 from Abcam

Prices $384.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-LDB1 antibody (ab96799) at 1/1000 dilution + Raji whole cell lysate at 30 µg

Anti-LDB1 antibody - ab48573 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-LDB1 antibody (ab48573) at 1 µg/ml + Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-LDB1 antibody - ab56555 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-LDB1 / CLIM2 Antibody (aa361-373) - LS-C19038 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-LDB1 Antibody - Western Blot. Western blot of affinity purified anti-LDB1 antibody shows detection of LDB1 protein (arrowhead) in Jurkat whole cell lysate. Approximately 30 ug of lysate was loaded prior to separation and transfer to nitrocellulose. Primary antibody was used at a 1:1800 dilution in 5% BLOTTO in PBS reacted overnight at 4C. The membrane was washed and reacted with a 1:20000 dilution of DyLight800 conjugated Gt-a-Rabbit IgG [H&L] MX ( for 45 min at room temperature (800 nm channel, green). Molecular weight estimation was made by comparison to prestained MW markers in lane M (700 nm channel, red). Fluorescence image was captured using the Odyssey Infrared Imaging System developed by LI-COR. IRDye is a trademark of LI-COR, Inc. Other detection systems will yield similar results.

Anti-LDB1 / CLIM2 Antibody (aa351-379, APC) - LS-C223028 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LDB1 / CLIM2 Antibody (aa351-379, AP) - LS-C223023 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LDB1 / CLIM2 Antibody (aa251-300) - LS-C30091 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: Jurkat Cell Lysate

Anti-LDB1 / CLIM2 Antibody (aa351-379, Biotin) - LS-C223029 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LDB1 / CLIM2 Antibody (aa351-379, FITC) - LS-C223030 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LDB1 / CLIM2 Antibody (aa351-379, PE) - LS-C223033 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LDB1 / CLIM2 Antibody (aa351-379, Azide-free, HRP) - LS-C223031 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LDB1 / CLIM2 Antibody (aa1-111) - LS-C308733 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-LDB1 / CLIM2 Antibody (aa350-379) - LS-C322617 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLIM2 / LDB1 Antibody (aa1-111, Azide-free) - LS-C327761 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
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