| Gene Symbol |
LDB1
|
| Entrez Gene |
8861
|
| Alt Symbol |
CLIM2, NLI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
LIM domain binding 1
|
| Other Description |
CLIM-2|LDB-1|LIM domain-binding factor CLIM2|LIM domain-binding factor-1|LIM domain-binding protein 1|carboxy terminal LIM domain protein 2|carboxyl-terminal LIM domain-binding protein 2|hLdb1|nuclear LIM interactor
|
| Swissprots |
O75479 Q9UGM4 O96010 B4DUC4 Q1EQX1 Q86U70
|
| Accessions |
CAB45408 CAB45409 EAW49722 EAW49723 EAW49724 Q86U70 AB016485 BAA31991 AB250384 BAE95402 AF064491 AAC28341 AF068652 AAC77818 AK300588 BAG62286 AK308481 BC000482 AAH00482 BC009246 AAH09246 BT007054 AAP35703 CV575131 DQ890772 ABM81698 DQ893933 ABM84859 XM_005270262 XP_005270319 XM_011540315 XP_011538617 NM_001113407 NP_001106878 NM_003893 NP_003884
|
| Function |
Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Expressed in a wide range of adult tissues including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:16815859}.
|
| Top Pathways |
Transcriptional misregulation in cancer
|
