| Gene Symbol | LDB1 |
|---|---|
| Entrez Gene | 8861 |
| Alt Symbol | CLIM2, NLI |
| Species | Human |
| Gene Type | protein-coding |
| Description | LIM domain binding 1 |
| Other Description | CLIM-2|LDB-1|LIM domain-binding factor CLIM2|LIM domain-binding factor-1|LIM domain-binding protein 1|carboxy terminal LIM domain protein 2|carboxyl-terminal LIM domain-binding protein 2|hLdb1|nuclear LIM interactor |
| Swissprots | O75479 Q9UGM4 O96010 B4DUC4 Q1EQX1 Q86U70 |
| Accessions | CAB45408 CAB45409 EAW49722 EAW49723 EAW49724 Q86U70 AB016485 BAA31991 AB250384 BAE95402 AF064491 AAC28341 AF068652 AAC77818 AK300588 BAG62286 AK308481 BC000482 AAH00482 BC009246 AAH09246 BT007054 AAP35703 CV575131 DQ890772 ABM81698 DQ893933 ABM84859 XM_005270262 XP_005270319 XM_011540315 XP_011538617 NM_001113407 NP_001106878 NM_003893 NP_003884 |
| Function | Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000305}. |
| Tissue Specificity | Expressed in a wide range of adult tissues including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:16815859}. |
| Top Pathways | Transcriptional misregulation in cancer |
CLIM-2 CRISPR/Cas9 KO Plasmid (h) - sc-401833 from Santa Cruz Biotechnology
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CLIM-2 HDR Plasmid (h) - sc-401833-HDR from Santa Cruz Biotechnology
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CLIM-2 Double Nickase Plasmid (h) - sc-401833-NIC from Santa Cruz Biotechnology
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CLIM-2 Double Nickase Plasmid (h2) - sc-401833-NIC-2 from Santa Cruz Biotechnology
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CLIM-2 CRISPR Activation Plasmid (h) - sc-401833-ACT from Santa Cruz Biotechnology
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CLIM-2 CRISPR Activation Plasmid (h2) - sc-401833-ACT-2 from Santa Cruz Biotechnology
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CLIM-2 Lentiviral Activation Particles (h) - sc-401833-LAC from Santa Cruz Biotechnology
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CLIM-2 Lentiviral Activation Particles (h2) - sc-401833-LAC-2 from Santa Cruz Biotechnology
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CLIM-2 siRNA (h) - sc-35072 from Santa Cruz Biotechnology
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CLIM-2 shRNA Plasmid (h) - sc-35072-SH from Santa Cruz Biotechnology
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CLIM-2 shRNA (h) Lentiviral Particles - sc-35072-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU126751 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11616 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11616 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05002 from Sigma-Aldrich
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LDB1 siRNA (Human) - CRH5852 from Cohesion Biosciences
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LDB1 RNAi - H00008861-R01 from Novus Biologicals
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shRNA set against Human LDB1 (NM_003893.4) - SHH329235 from Creative biogene
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shRNA set against Human LDB1(NM_003893.4) - SHH145001 from Creative biogene
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Human LDB1 siRNA - orb266354 from Biorbyt
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LDB1 shRNA Plasmid (Human) - CHH5852 from Cohesion Biosciences
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LDB1 miRNA 3'UTR clone - MiUTR1H-05619 from Creative biogene
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LDB1 miRNA 3'UTR clone - MiUTR3H-05982 from Creative biogene
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