| Gene Symbol |
PFN3
|
| Entrez Gene |
345456
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
profilin 3
|
| Other Description |
profilin III|profilin-3
|
| Swissprots |
A2RUL3 P60673
|
| Accessions |
EAW85006 P60673 AA909745 BC132952 AAI32953 BC132954 AAI32955 NM_001029886 NP_001025057
|
| Function |
Binds to actin and affects the structure of the cytoskeleton. Slightly reduces actin polymerization. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). May be involved in spermatogenesis. {ECO:0000269|PubMed:19419568}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Testis specific.
|
| Top Pathways |
Salmonella infection, Rap1 signaling pathway, Regulation of actin cytoskeleton
|