| Gene Symbol |
EPN1
|
| Entrez Gene |
29924
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
epsin 1
|
| Other Description |
EH domain-binding mitotic phosphoprotein|EPS-15-interacting protein 1|epsin-1
|
| Swissprots |
Q9HA18 Q86ST3 Q9Y6I3
|
| Accessions |
CAE91463 EAW72405 EAW72406 EAW72407 EAW72408 Q9Y6I3 AF073727 AAD38326 AK022454 BAB14041 AK300545 BAG62253 AK314690 BC044651 AAH44651 BU634413 DA657018 HQ257921 ADR82675 XM_005258829 XP_005258886 XM_005258830 XP_005258887 XM_011526880 XP_011525182 XM_011526881 XP_011525183 NM_001130071 NP_001123543 NM_001130072 NP_001123544 NM_013333 NP_037465
|
| Function |
Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis. {ECO:0000250, ECO:0000269|PubMed:10557078}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Note=Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity). {ECO:0000250}.
|
| Top Pathways |
Endocytosis
|
![Western Blot: Epsin 1 Overexpression Lysate (Adult Normal) [NBL1-10297] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Epsin 1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4750_Epsin%25201%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10297-img0002.jpg)