Gene Symbol | EPN1 |
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Entrez Gene | 29924 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | epsin 1 |
Other Description | EH domain-binding mitotic phosphoprotein|EPS-15-interacting protein 1|epsin-1 |
Swissprots | Q9HA18 Q86ST3 Q9Y6I3 |
Accessions | CAE91463 EAW72405 EAW72406 EAW72407 EAW72408 Q9Y6I3 AF073727 AAD38326 AK022454 BAB14041 AK300545 BAG62253 AK314690 BC044651 AAH44651 BU634413 DA657018 HQ257921 ADR82675 XM_005258829 XP_005258886 XM_005258830 XP_005258887 XM_011526880 XP_011525182 XM_011526881 XP_011525183 NM_001130071 NP_001123543 NM_001130072 NP_001123544 NM_013333 NP_037465 |
Function | Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis. {ECO:0000250, ECO:0000269|PubMed:10557078}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Note=Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity). {ECO:0000250}. |
Top Pathways | Endocytosis |
epsin 1 CRISPR/Cas9 KO Plasmid (h) - sc-401566 from Santa Cruz Biotechnology
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epsin 1 HDR Plasmid (h) - sc-401566-HDR from Santa Cruz Biotechnology
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epsin 1 Double Nickase Plasmid (h) - sc-401566-NIC from Santa Cruz Biotechnology
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epsin 1 Double Nickase Plasmid (h2) - sc-401566-NIC-2 from Santa Cruz Biotechnology
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epsin 1 CRISPR Activation Plasmid (h) - sc-401566-ACT from Santa Cruz Biotechnology
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epsin 1 CRISPR Activation Plasmid (h2) - sc-401566-ACT-2 from Santa Cruz Biotechnology
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epsin 1 Lentiviral Activation Particles (h) - sc-401566-LAC from Santa Cruz Biotechnology
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epsin 1 Lentiviral Activation Particles (h2) - sc-401566-LAC-2 from Santa Cruz Biotechnology
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epsin 1 siRNA (h) - sc-35323 from Santa Cruz Biotechnology
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epsin 1 shRNA Plasmid (h) - sc-35323-SH from Santa Cruz Biotechnology
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epsin 1 shRNA (h) Lentiviral Particles - sc-35323-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN7926 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7926 from Sigma-Aldrich
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EPN1 siRNA (Human) - CRH9271 from Cohesion Biosciences
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EPN1 - MBS8209427 from MyBioSource
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shRNA set against Human EPN1 (NM_013333.3) - SHH286569 from Creative biogene
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Human EPN1 siRNA - orb269773 from Biorbyt
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EPN1 shRNA Plasmid (Human) - CHH9271 from Cohesion Biosciences
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EPN1 miRNA 3'UTR clone - MiUTR3H-09092 from Creative biogene
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EPN1 miRNA 3'UTR clone - MiUTR3H-09093 from Creative biogene
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EPN1 miRNA 3'UTR clone - MiUTR3H-09094 from Creative biogene
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