| Gene Symbol |
METTL3
|
| Entrez Gene |
56339
|
| Alt Symbol |
IME4, M6A, MT-A70, Spo8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
methyltransferase like 3
|
| Other Description |
N6-adenosine-methyltransferase 70 kDa subunit|adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase|mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase|mRNA m(6)A methyltransferase|methyltransferase-like protein 3
|
| Swissprots |
O14736 Q86U44 Q9HB32 Q86V05
|
| Accessions |
AAB71850 AAG13956 EAW66379 Q86U44 AK000222 AK093509 BAG52732 AK097873 AK098655 AK300289 BAG62046 AK304251 BAG65118 AK304570 BAG65361 BC001650 AAH01650 BC003031 AAH03031 BC014427 BC052244 AAH52244 BX247964 CAD62303 CA311761 DC295053 EU446825 ABZ92354 XM_006720206 XP_006720269 XM_011536968 XP_011535270 XM_011536969 XP_011535271 NM_019852 NP_062826
|
| Function |
N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock. N6- methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing and processing. M6A regulates the length of the ciracadian clock: acts as a early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop. {ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:9409616}.
|
| Subcellular Location |
Nucleus speckle {ECO:0000269|PubMed:9409616}. Note=Colocalizes with speckles in interphase nuclei. Suggesting that it may be associated with nuclear pre-mRNA splicing components.
|
| Tissue Specificity |
Widely expressed at low level. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:9409616}.
|