METTL3

Gene Symbol METTL3
Entrez Gene 56339
Alt Symbol IME4, M6A, MT-A70, Spo8
Species Human
Gene Type protein-coding
Description methyltransferase like 3
Other Description N6-adenosine-methyltransferase 70 kDa subunit|adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase|mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase|mRNA m(6)A methyltransferase|methyltransferase-like protein 3
Swissprots O14736 Q86U44 Q9HB32 Q86V05
Accessions AAB71850 AAG13956 EAW66379 Q86U44 AK000222 AK093509 BAG52732 AK097873 AK098655 AK300289 BAG62046 AK304251 BAG65118 AK304570 BAG65361 BC001650 AAH01650 BC003031 AAH03031 BC014427 BC052244 AAH52244 BX247964 CAD62303 CA311761 DC295053 EU446825 ABZ92354 XM_006720206 XP_006720269 XM_011536968 XP_011535270 XM_011536969 XP_011535271 NM_019852 NP_062826
Function N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock. N6- methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing and processing. M6A regulates the length of the ciracadian clock: acts as a early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop. {ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:9409616}.
Subcellular Location Nucleus speckle {ECO:0000269|PubMed:9409616}. Note=Colocalizes with speckles in interphase nuclei. Suggesting that it may be associated with nuclear pre-mRNA splicing components.
Tissue Specificity Widely expressed at low level. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:9409616}.

METTL3 CRISPR/Cas9 KO Plasmid (h) - sc-404029 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

METTL3 HDR Plasmid (h) - sc-404029-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

METTL3 Double Nickase Plasmid (h) - sc-404029-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

METTL3 Double Nickase Plasmid (h2) - sc-404029-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

METTL3 CRISPR Activation Plasmid (h) - sc-404029-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

METTL3 CRISPR Activation Plasmid (h2) - sc-404029-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

METTL3 Lentiviral Activation Particles (h) - sc-404029-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

METTL3 Lentiviral Activation Particles (h2) - sc-404029-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

METTL3 siRNA (h) - sc-92172 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

METTL3 shRNA Plasmid (h) - sc-92172-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

METTL3 shRNA (h) Lentiviral Particles - sc-92172-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU063661 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN13233 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

METTL3 siRNA (Human) - CRJ1136 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Methyltransferase like 3 RNAi - H00056339-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human METTL3(NM_019852.3) - SHH185735 from Creative biogene

Category siRNA
Species Reactivities Human

Human METTL3 siRNA - orb271637 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

METTL3 shRNA Plasmid (Human) - CHJ1136 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

METTL3 miRNA 3'UTR clone - MiUTR1H-06224 from Creative biogene

Species Reactivities Human
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