METTL3

Gene Symbol	METTL3
Entrez Gene	56339
Alt Symbol	IME4, M6A, MT-A70, Spo8
Species	Human
Gene Type	protein-coding
Description	methyltransferase like 3
Other Description	N6-adenosine-methyltransferase 70 kDa subunit|adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase|mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase|mRNA m(6)A methyltransferase|methyltransferase-like protein 3
Swissprots	O14736 Q86U44 Q9HB32 Q86V05
Accessions	AAB71850 AAG13956 EAW66379 Q86U44 AK000222 AK093509 BAG52732 AK097873 AK098655 AK300289 BAG62046 AK304251 BAG65118 AK304570 BAG65361 BC001650 AAH01650 BC003031 AAH03031 BC014427 BC052244 AAH52244 BX247964 CAD62303 CA311761 DC295053 EU446825 ABZ92354 XM_006720206 XP_006720269 XM_011536968 XP_011535270 XM_011536969 XP_011535271 NM_019852 NP_062826
Function	N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock. N6- methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing and processing. M6A regulates the length of the ciracadian clock: acts as a early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop. {ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:9409616}.
Subcellular Location	Nucleus speckle {ECO:0000269|PubMed:9409616}. Note=Colocalizes with speckles in interphase nuclei. Suggesting that it may be associated with nuclear pre-mRNA splicing components.
Tissue Specificity	Widely expressed at low level. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:9409616}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Methyltransferase like 3 full length protein - ab163377 from Abcam Category Protein Source Wheat germ Species Human

METTL3 Antibody Blocking Peptide - LS-E12287 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

METTL3 Antibody Blocking Peptide - LS-E12288 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

METTL3 Antibody Blocking Peptide - LS-E14230 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

METTL3 Antibody Blocking Peptide - LS-E14231 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Methyltransferase like 3 Recombinant Protein - H00056339-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

METTL3 - H00056339-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

METTL3 - H00056339-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

METTL3 fusion protein - Ag7110 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, T-HIS Species Human

Recombinant Human METTL3, His-tagged - METTL3-836H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human N6-adenosine-methyltransferase 70 kDa subunit(METTL3) - CSB-YP773027HU CSB-EP773027HU CSB-BP773027HU CSB-MP773027HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

METTL3 Protein - abx163316 from Abbexa Category Protein Species Human, Mouse

METTL3 - TP300869 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Methyltransferase like 3 Protein - NBP1-89576PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

METTL3 Peptide, Human - M34GP09440H from Creative Peptides Category Peptide Source Synthetic. Species Human

N6-adenosine-methyltransferase 70 kDa subunit (METTL3), Recombinant Protein - MBS1420307 from MyBioSource Category Protein Prices $1,380.00, $1,380.00, $1,610.00, $1,610.00, $2,275.00, $2,275.00, $2,715.00, $2,715.00, $2,715.00, $4,495.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant METTL3 protein - 31567 from ActiveMotif Category Protein Prices $395.00 Sizes 20 µg Source Baculovirus Species Human

Recombinant METTL3 / METTL14 complex - 31570 from ActiveMotif Prices $415.00 Sizes 20 µg Source Baculovirus Species Human

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