METTL3

Gene Symbol	METTL3
Entrez Gene	56339
Alt Symbol	IME4, M6A, MT-A70, Spo8
Species	Human
Gene Type	protein-coding
Description	methyltransferase like 3
Other Description	N6-adenosine-methyltransferase 70 kDa subunit\|adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase\|mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase\|mRNA m(6)A methyltransferase\|methyltransferase-like protein 3
Swissprots	O14736 Q86U44 Q9HB32 Q86V05
Accessions	AAB71850 AAG13956 EAW66379 Q86U44 AK000222 AK093509 BAG52732 AK097873 AK098655 AK300289 BAG62046 AK304251 BAG65118 AK304570 BAG65361 BC001650 AAH01650 BC003031 AAH03031 BC014427 BC052244 AAH52244 BX247964 CAD62303 CA311761 DC295053 EU446825 ABZ92354 XM_006720206 XP_006720269 XM_011536968 XP_011535270 XM_011536969 XP_011535271 NM_019852 NP_062826
Function	N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock. N6- methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing and processing. M6A regulates the length of the ciracadian clock: acts as a early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop. {ECO:0000269\|PubMed:22575960, ECO:0000269\|PubMed:24284625, ECO:0000269\|PubMed:9409616}.
Subcellular Location	Nucleus speckle {ECO:0000269\|PubMed:9409616}. Note=Colocalizes with speckles in interphase nuclei. Suggesting that it may be associated with nuclear pre-mRNA splicing components.
Tissue Specificity	Widely expressed at low level. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. {ECO:0000269\|PubMed:9409616}.

METTL3 (E-14) - sc-104990 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

METTL3 (Q-12) - sc-104991 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

METTL3 (Q-12): sc-104991. Western blot analysis of METTL3 expression in HEK293 whole cell lysate.

METTL3 (B-23) - sc-133783 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

METTL3 (B-23): sc-133783. Western blot analysis of METTL3 expression in Raji whole cell lysate.

Anti-Methyltransferase like 3 antibody - ab66660 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-Methyltransferase like 3 antibody (ab66660) at 5 µg/ml + fetal thymus lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-Methyltransferase like 3 antibody - ab154730 from Abcam

Host	Rabbit
Clonality	Polyclonal

Anti-Methyltransferase like 3 antibody (ab154730) at 1/10000 dilution + MOLT4 whole cell lysate at 30 µg

Anti-Methyltransferase like 3 antibody - ab49253 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-Methyltransferase like 3 antibody (ab49253) at 5 µg/ml + Raji cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG 1/50,000 - 1/100,000

Anti-Methyltransferase like 3 antibody - ab98009 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-Methyltransferase like 3 antibody (ab98009) at 1 µg/ml ( in 5% skim milk / PBS buffer) + Human fetal brain lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-METTL3 Antibody (aa206-255) - LS-C31297 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-METTL3 Antibody (C-Terminus) - LS-C134988 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

METTL3 antibody LS-C134988 Western blot of HepG2 Cell lysate. Antibody concentration 1 ug/ml.

Anti-METTL3 Antibody (aa503-552) - LS-C107543 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

METTL3 antibody LS-C107543 Western blot of Fetal Brain lysate.

Anti-METTL3 Antibody (N-Terminus) - LS-C31298 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

METTL3 antibody LS-C31298 was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.

Anti-METTL3 Antibody (aa1-50) - LS-C288359 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Detection of Human METTL3/MT-A70 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-METTL3/MT-A70 used at a dilution of 1:1000 (0.2 ug/ml). Detection: DAB.

Anti-METTL3 Antibody (aa530-580) - LS-C288361 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-METTL3 Antibody (aa1-50) - LS-C286579 from LifeSpan Bioscience

Prices	$415.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Detection of Mouse METTL3/MT-A70 by Immunohistochemistry. Sample: FFPE section of mouse teratoma. Antibody: Affinity purified rabbit anti-METTL3/MT-A70 used at a dilution of 1:100.

Methyltransferase like 3 Antibody - H00056339-B01P from Novus Biologicals

Prices	$359.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Western Blot: Methyltransferase like 3 Antibody [H00056339-B01P] - Analysis of METTL3 expression in human colon.

Methyltransferase like 3 Antibody - NB100-77310 from Novus Biologicals

Prices	$359.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry: Methyltransferase like 3 Antibody [NB100-77310] - Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti- METTL3/MT-A70 used at a dilution of 1:1,000 (0.2ug/ml). Detection: DAB

Methyltransferase like 3 Antibody - NBP1-89576 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: Methyltransferase like 3 Antibody [NBP1-89576] - Lane 1: Marker [kDa] 219, 112, 85, 49, 32, 25, 18<br/>Lane 2: Human cell line RT-4<br/>Lane 3: Human cell line U-251MG sp<br/>Lane 4: Human cell line A-431<br/>Lane 5: Human liver tissue<br/>Lane 6: Human tonsil tissue

Methyltransferase like 3 Antibody - NB100-77311 from Novus Biologicals

Prices	$359.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry-Paraffin: Methyltransferase like 3 Antibody [NB100-77311] - Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti- METTL3/MT-A70 used at a dilution of 1:1,000 (1 ug/ml). Detection: DAB

Anti-METTL3 antibody produced in rabbit - SAB2104747 from Sigma-Aldrich

Prices	$347.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-METTL3, antibody produced in rabbit: <B>Cat. No. SAB2104747</B>: Immunoblotting analysis of METTL3 in fetal brain tissue lysate with METTL3 anitbody at 1 μg/mL.

Anti-METTL3 (AB2) antibody produced in rabbit - AV39390 from Sigma-Aldrich

Prices	$267.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-METTL3 (ab2): <B>Cat. No. AV39390</B>: Immunohistochemistry of METTL3 in Human Intestine tissue with METTL3 antibody at 4-8 μg/mL.

Anti-METTL3 antibody produced in rabbit - HPA001299 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-METTL3: <B>Cat. No. HPA001299</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human appendix tissue showing cytoplasmic and/or membranous staining in lymphoid tissue.

METTL3 antibody - middle region (ARP34590_T100) - ARP34590_T100 from Aviva Systems Biology

Prices	$229.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

METTL3 antibody - C-terminal region (ARP34591_P050) - ARP34591_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

METTL3 antibody - N-terminal region (ARP39390_T100) - ARP39390_T100 from Aviva Systems Biology

Prices	$229.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

METTL3 antibody - middle region (ARP39391_P050) - ARP39391_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

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