| Gene Symbol |
FARP1
|
| Entrez Gene |
10160
|
| Alt Symbol |
CDEP, FARP1-IT1, PLEKHC2, PPP1R75
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
|
| Other Description |
FERM, RhoGEF and pleckstrin domain-containing protein 1|PH domain-containing family C member 2|chondrocyte-derived ezrin-like protein|pleckstrin homology domain-containing family C member 2|protein phosphatase 1, regulatory subunit 75
|
| Swissprots |
Q5JVI9 Q6IQ29 Q9Y4F1
|
| Accessions |
EAX08982 Q9Y4F1 AB008430 BAA24267 AI273567 AI274149 AI381545 AK095747 AK123565 AM393180 CAL38058 AM393217 CAL38095 AM393453 CAL38331 AW270133 AW514534 BC041595 AAH41595 BC053593 BC065020 BC071592 AAH71592 BE463494 BM763139 BQ014327 BX115123 CF994038 DB498534 XM_011521046 XP_011519348 NM_001001715 NP_001001715 NM_001286839 NP_001273768 NM_005766 NP_005757
|
| Function |
Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell junction, synapse, synaptosome {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Recruited to the cell membrane via interaction with CADM1. {ECO:0000250}.
|
| Tissue Specificity |
Detected in cAMP-treated chondrocytes, but not in untreated chondrocytes. Detected in fetal brain, heart and spleen, and in adult testis, kidney and lung. {ECO:0000269|PubMed:9425278}.
|