| Gene Symbol | FARP1 |
|---|---|
| Entrez Gene | 10160 |
| Alt Symbol | CDEP, FARP1-IT1, PLEKHC2, PPP1R75 |
| Species | Human |
| Gene Type | protein-coding |
| Description | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) |
| Other Description | FERM, RhoGEF and pleckstrin domain-containing protein 1|PH domain-containing family C member 2|chondrocyte-derived ezrin-like protein|pleckstrin homology domain-containing family C member 2|protein phosphatase 1, regulatory subunit 75 |
| Swissprots | Q5JVI9 Q6IQ29 Q9Y4F1 |
| Accessions | EAX08982 Q9Y4F1 AB008430 BAA24267 AI273567 AI274149 AI381545 AK095747 AK123565 AM393180 CAL38058 AM393217 CAL38095 AM393453 CAL38331 AW270133 AW514534 BC041595 AAH41595 BC053593 BC065020 BC071592 AAH71592 BE463494 BM763139 BQ014327 BX115123 CF994038 DB498534 XM_011521046 XP_011519348 NM_001001715 NP_001001715 NM_001286839 NP_001273768 NM_005766 NP_005757 |
| Function | Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell junction, synapse, synaptosome {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Recruited to the cell membrane via interaction with CADM1. {ECO:0000250}. |
| Tissue Specificity | Detected in cAMP-treated chondrocytes, but not in untreated chondrocytes. Detected in fetal brain, heart and spleen, and in adult testis, kidney and lung. {ECO:0000269|PubMed:9425278}. |
FARP1 CRISPR/Cas9 KO Plasmid (h) - sc-402352 from Santa Cruz Biotechnology
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FARP1 HDR Plasmid (h) - sc-402352-HDR from Santa Cruz Biotechnology
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FARP1 Double Nickase Plasmid (h) - sc-402352-NIC from Santa Cruz Biotechnology
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FARP1 Double Nickase Plasmid (h2) - sc-402352-NIC-2 from Santa Cruz Biotechnology
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FARP1 CRISPR Activation Plasmid (h) - sc-402352-ACT from Santa Cruz Biotechnology
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FARP1 CRISPR Activation Plasmid (h2) - sc-402352-ACT-2 from Santa Cruz Biotechnology
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FARP1 Lentiviral Activation Particles (h) - sc-402352-LAC from Santa Cruz Biotechnology
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FARP1 Lentiviral Activation Particles (h2) - sc-402352-LAC-2 from Santa Cruz Biotechnology
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FARP1 siRNA (h) - sc-77315 from Santa Cruz Biotechnology
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FARP1 shRNA Plasmid (h) - sc-77315-SH from Santa Cruz Biotechnology
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FARP1 shRNA (h) Lentiviral Particles - sc-77315-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU012591 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8482 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8482 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09485 from Sigma-Aldrich
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FARP1 siRNA (Human) - CRH6859 from Cohesion Biosciences
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FARP1 - MBS8217475 from MyBioSource
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shRNA set against Human FARP1 (NM_005766.2) - SHH292414 from Creative biogene
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shRNA set against Human FARP1(NM_001001715.2) - SHH049241 from Creative biogene
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shRNA set against Human FARP1(NM_005766.2) - SHH049259 from Creative biogene
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Human FARP1 siRNA - orb267361 from Biorbyt
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FARP1 shRNA Plasmid (Human) - CHH6859 from Cohesion Biosciences
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FARP1 miRNA 3'UTR clone - MiUTR1H-03514 from Creative biogene
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FARP1 miRNA 3'UTR clone - MiUTR1H-03515 from Creative biogene
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