KPNA4

Gene Symbol KPNA4
Entrez Gene 3840
Alt Symbol IPOA3, QIP1, SRP3
Species Human
Gene Type protein-coding
Description karyopherin alpha 4 (importin alpha 3)
Other Description importin alpha Q1|importin subunit alpha-3|importin subunit alpha-4|karyopherin subunit alpha-4
Swissprots A8K4S6 D3DNM2 O00629 O00190
Accessions EAW78631 EAW78632 EAW78633 O00629 AB002533 BAA19546 AF038199 AK021602 AK055675 AK129841 AK291041 BAF83730 BC007458 AAH07458 BC016754 AAH16754 BC028691 AAH28691 BC034493 AAH34493 BC052814 DQ890866 ABM81792 DQ894021 ABM84947 U93240 AAC25605 Y12393 CAA73025 NM_002268 NP_002259
Function Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus U
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Tissue Specificity Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas, but barely detectable in kidney, thymus, colon and peripheral blood leukocytes.

QIP1 (B-6) - sc-390535 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
QIP1 (B-6): sc-390535. Western blot analysis of QIP1 expression in HeLa (A) and K-562 (B) whole cell lysates.

QIP1 (P-15) - sc-55270 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

QIP1 (3D10) - sc-101547 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
QIP1 (3D10): sc-101547. Western blot analysis of QIP1 expression in HeLa (A), K-562 (B) and Ramos (C) whole cell lysates.

QIP1 (K-15) - sc-55267 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
QIP1 (K-15): sc-55267. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing cytoplasmic and nuclear staining of cells in seminiferous ducts and cytoplasmic staining of Leydig cells.

QIP1 (G-15) - sc-55266 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

QIP1 (H-161) - sc-366197 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
QIP1 (H-161): sc-366197. Western blot analysis of QIP1 expression in Hs 181 Tes (A), HeLa (B) and NTERA-2 cl.D1 (C) whole cell lysates.

Anti-KPNA4 antibody - ab117615 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab117615, at 5 µg/ml, staining KPNA4 in Formalin-fixed, Paraffin-embedded Human Breast tissue by Immunohistochemistry.

Anti-KPNA4 antibody [2500D3a] - ab53751 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2500D3a
Anti-KPNA4 antibody [2500D3a] (ab53751) + Recombinant immunising protein fragment

Anti-QIP1 / KPNA4 Antibody (N-Terminus) IHC-plus™ - LS-B5342 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KPNA4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5342 concentration 5 ug/ml.

Anti-QIP1 / KPNA4 Antibody (aa459-521) - LS-C185791 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded H1299 xenograft using KPNA4 antibody at 1:500 dilution.

Anti-QIP1 / KPNA4 Antibody - LS-C331831 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human stomach tissue using KPNA4 antibody at dilution of 1:200 (x400 lens).

Anti-QIP1 / KPNA4 Antibody (clone 2500D3a) - LS-C342520 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2500D3a
Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-KPNA4 mAb.

Anti-QIP1 / KPNA4 Antibody (aa471-521) - LS-C286560 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Detection of Mouse KPNA4 by Immunohistochemistry. Sample: FFPE section of mouse teratoma. Antibody: Affinity purified rabbit anti-KPNA4 used at a dilution of 1:250.

Anti-QIP1 / KPNA4 Antibody - LS-C71264 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-QIP1 / KPNA4 Antibody (aa38-87) - LS-C81902 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Hela cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-QIP1 / KPNA4 Antibody (N-Terminus, AP) - LS-C225716 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-QIP1 / KPNA4 Antibody (N-Terminus, APC) - LS-C225718 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-QIP1 / KPNA4 Antibody (N-Terminus, Biotin) - LS-C225719 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-QIP1 / KPNA4 Antibody (N-Terminus, FITC) - LS-C225720 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-QIP1 / KPNA4 Antibody (N-Terminus, PE) - LS-C225721 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-QIP1 / KPNA4 Antibody (N-Terminus, Azide-free, HRP) - LS-C225722 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-QIP1 / KPNA4 Antibody (aa1-30) - LS-C97609 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
The anti-Importin alpha-3 antibody is used in Western blot to detect Importin alpha-3 in HeLa (left), mouse brain (middle), and HepG2 (right)cell line/tissue lysates.

Anti-QIP1 / KPNA4 Antibody (clone 2500D3a) - LS-C184477 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2500D3a
Western blot of immunized recombinant protein using KPNA4 antibody.

Anti-QIP1 / KPNA4 Antibody (N-Terminus) - LS-C327696 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-QIP1 / KPNA4 Antibody - LS-C341465 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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