KPNA4

Gene Symbol	KPNA4
Entrez Gene	3840
Alt Symbol	IPOA3, QIP1, SRP3
Species	Human
Gene Type	protein-coding
Description	karyopherin alpha 4 (importin alpha 3)
Other Description	importin alpha Q1|importin subunit alpha-3|importin subunit alpha-4|karyopherin subunit alpha-4
Swissprots	A8K4S6 D3DNM2 O00629 O00190
Accessions	EAW78631 EAW78632 EAW78633 O00629 AB002533 BAA19546 AF038199 AK021602 AK055675 AK129841 AK291041 BAF83730 BC007458 AAH07458 BC016754 AAH16754 BC028691 AAH28691 BC034493 AAH34493 BC052814 DQ890866 ABM81792 DQ894021 ABM84947 U93240 AAC25605 Y12393 CAA73025 NM_002268 NP_002259
Function	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus U
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Tissue Specificity	Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas, but barely detectable in kidney, thymus, colon and peripheral blood leukocytes.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KPNA4 full length protein - ab114626 from Abcam Category Protein Source Wheat germ Species Human

Human KPNA4 peptide - ab23144 from Abcam Category Peptide Species Human

QIP1 / KPNA4 Antibody Blocking Peptide - LS-E19701 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

QIP1 / KPNA4 Antibody Blocking Peptide - LS-E25666 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

QIP1 / KPNA4 Antibody Blocking Peptide - LS-E31005 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human Importin alpha 3/KPNA4 Protein - H00003840-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Importin alpha 3/KPNA4 Blocking Peptide - NBP1-76300PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

KPNA4 blocking peptide - GTX26039-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

KPNA4 Peptide - AC21-0496-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

KPNA4 / Importin alpha-4 - H00003840-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

KPNA4 / Importin alpha-4 - H00003840-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

KPNA4 / Importin alpha-4 control peptide - AP26274CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

KPNA4 Peptide - 45-814P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse

KPNA4 Peptide - 5987P from ProSci Category Peptide Species Human

KPNA4 fusion protein - ag3133 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human KPNA4 Protein, GST-tagged - KPNA4-29909TH from Creative Biomart Category Protein Source Wheat Germ Species Human

Recombinant Human Importin subunit alpha-4(KPNA4) - CSB-YP012486HU CSB-EP012486HU CSB-BP012486HU CSB-MP012486HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

KPNA4 / Importin alpha-4 - TP305448 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

KPNA4/IPOA3, Peptide - MBS425486 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Bovine

Importin alpha 3/KPNA4 Recombinant Protein Antigen - NBP2-14173PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Importin alpha 3/KPNA4 Recombinant Protein Antigen - NBP2-38541PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Importin-alpha-4-KPNA4Antibody-C-term-Blocking-peptide - BP1968a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Importin-alpha-4-KPNA4Antibody-N-term-Blocking-peptide - BP1968b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

KPNA4 Peptide, Human - M34GP08339H from Creative Peptides Category Peptide Source Synthetic. Species Human

Importin subunit alpha-4 (KPNA4), Recombinant Protein - MBS1158483 from MyBioSource Category Protein Prices $1,310.00, $1,310.00, $1,530.00, $1,530.00, $2,160.00, $2,160.00, $2,625.00, $2,625.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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