KPNA4

Gene Symbol KPNA4
Entrez Gene 3840
Alt Symbol IPOA3, QIP1, SRP3
Species Human
Gene Type protein-coding
Description karyopherin alpha 4 (importin alpha 3)
Other Description importin alpha Q1|importin subunit alpha-3|importin subunit alpha-4|karyopherin subunit alpha-4
Swissprots A8K4S6 D3DNM2 O00629 O00190
Accessions EAW78631 EAW78632 EAW78633 O00629 AB002533 BAA19546 AF038199 AK021602 AK055675 AK129841 AK291041 BAF83730 BC007458 AAH07458 BC016754 AAH16754 BC028691 AAH28691 BC034493 AAH34493 BC052814 DQ890866 ABM81792 DQ894021 ABM84947 U93240 AAC25605 Y12393 CAA73025 NM_002268 NP_002259
Function Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus U
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Tissue Specificity Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas, but barely detectable in kidney, thymus, colon and peripheral blood leukocytes.

KPNA4-Over-expression-Lysate - LY11655a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag KPNA4 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the KPNA4 gene

KPNA4 overexpression lysate - LY400822 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

KPNA4 293 Cell Lysate - 400784 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

Importin alpha 3/KPNA4 Overexpression Lysate (Native) - NBL1-12372 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: KPNA4 Overexpression Lysate (Adult Normal) [NBL1-12372] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KPNA4.

KPNA4 Over-expression Lysate Product - GWB-3E0860 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human KPNA4 Knockdown Stable Cell Line - CSC-DC008339 from Creative biogene

Category Cell Line
Species Human
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