| Gene Symbol | KPNA4 |
|---|---|
| Entrez Gene | 3840 |
| Alt Symbol | IPOA3, QIP1, SRP3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | karyopherin alpha 4 (importin alpha 3) |
| Other Description | importin alpha Q1|importin subunit alpha-3|importin subunit alpha-4|karyopherin subunit alpha-4 |
| Swissprots | A8K4S6 D3DNM2 O00629 O00190 |
| Accessions | EAW78631 EAW78632 EAW78633 O00629 AB002533 BAA19546 AF038199 AK021602 AK055675 AK129841 AK291041 BAF83730 BC007458 AAH07458 BC016754 AAH16754 BC028691 AAH28691 BC034493 AAH34493 BC052814 DQ890866 ABM81792 DQ894021 ABM84947 U93240 AAC25605 Y12393 CAA73025 NM_002268 NP_002259 |
| Function | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus U |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
| Tissue Specificity | Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas, but barely detectable in kidney, thymus, colon and peripheral blood leukocytes. |
karyopherin alpha 4 (importin alpha 3) , ELISA Kit - MBS9343361 from MyBioSource
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Karyopherin Alpha 4 (KPNa4), ELISA Kit - MBS9313060 from MyBioSource
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Human KPNA4 ELISA Kit - E021350 from Biobool
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anti-KPNA4 / IPOA3 antibody - ARG63399 from Arigo Biolaboratories
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anti-KPNA4 / IPOA3 antibody - ARG55274 from Arigo Biolaboratories
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Importin subunit alpha-3 (KPNA3), ELISA Kit - MBS2610257 from MyBioSource
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Importin subunit alpha-3, ELISA Kit - MBS2604525 from MyBioSource
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Importin subunit alpha-3, ELISA Kit - MBS2608176 from MyBioSource
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Importin subunit alpha-3, ELISA Kit - MBS2607514 from MyBioSource
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Importin subunit alpha-3, ELISA Kit - MBS2607428 from MyBioSource
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Importin subunit alpha-3, ELISA Kit - MBS2606405 from MyBioSource
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Importin subunit alpha-3, ELISA Kit - MBS2604657 from MyBioSource
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Importin subunit alpha-3, ELISA Kit - MBS2605063 from MyBioSource
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Importin subunit alpha-3, ELISA Kit - MBS2605666 from MyBioSource
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