| Gene Symbol | TRAP1 |
|---|---|
| Entrez Gene | 10131 |
| Alt Symbol | HSP 75, HSP75, HSP90L, TRAP-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | TNF receptor-associated protein 1 |
| Other Description | TNFR-associated protein 1|heat shock protein 75 kDa, mitochondrial|tumor necrosis factor type 1 receptor-associated protein |
| Swissprots | Q9UHL5 F5H897 B4DR68 D3DUC8 O75235 O43642 Q12931 |
| Accessions | AAC24722 EAW85338 EAW85339 EAW85340 EAW85341 EAW85342 Q12931 AB209805 BAD93042 AF043254 AAC02679 AF154108 AAF15314 AJ890085 CAI64498 AK057620 BAG51942 AK093344 BAC04139 AK223049 BAD96769 AK223076 BAD96796 AK223205 BAD96925 AK299127 BAG61180 BC000406 BC001455 AAH01455 BC002994 BC018950 AAH18950 BC023585 AAH23585 DB452880 DQ893476 ABM84402 DQ896346 ABM87345 JX481354 AFS69159 U12595 AAA87704 XM_011522345 XP_011520647 NM_001272049 NP_001258978 NM_016292 NP_057376 |
| Function | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}. |
| Subcellular Location | Mitochondrion {ECO:0000269|PubMed:23564345}. Mitochondrion inner membrane {ECO:0000269|PubMed:23564345}. Mitochondrion matrix {ECO:0000269|PubMed:23564345}. |
| Tissue Specificity | Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is higly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors. {ECO:0000269|PubMed:23564345}. |