TRAP1

Gene Symbol	TRAP1
Entrez Gene	10131
Alt Symbol	HSP 75, HSP75, HSP90L, TRAP-1
Species	Human
Gene Type	protein-coding
Description	TNF receptor-associated protein 1
Other Description	TNFR-associated protein 1|heat shock protein 75 kDa, mitochondrial|tumor necrosis factor type 1 receptor-associated protein
Swissprots	Q9UHL5 F5H897 B4DR68 D3DUC8 O75235 O43642 Q12931
Accessions	AAC24722 EAW85338 EAW85339 EAW85340 EAW85341 EAW85342 Q12931 AB209805 BAD93042 AF043254 AAC02679 AF154108 AAF15314 AJ890085 CAI64498 AK057620 BAG51942 AK093344 BAC04139 AK223049 BAD96769 AK223076 BAD96796 AK223205 BAD96925 AK299127 BAG61180 BC000406 BC001455 AAH01455 BC002994 BC018950 AAH18950 BC023585 AAH23585 DB452880 DQ893476 ABM84402 DQ896346 ABM87345 JX481354 AFS69159 U12595 AAA87704 XM_011522345 XP_011520647 NM_001272049 NP_001258978 NM_016292 NP_057376
Function	Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}.
Subcellular Location	Mitochondrion {ECO:0000269|PubMed:23564345}. Mitochondrion inner membrane {ECO:0000269|PubMed:23564345}. Mitochondrion matrix {ECO:0000269|PubMed:23564345}.
Tissue Specificity	Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is higly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors. {ECO:0000269|PubMed:23564345}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human TRAP1 full length protein - ab123775 from Abcam Category Protein Prices $239.00 Sizes 10 µg Source E. coli Species Human

TRAP1 / HSP75 Antibody Blocking Peptide - LS-E2998 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRAP1 / HSP75 Antibody Blocking Peptide - LS-E10514 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TRAP1 Protein - H00010131-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TRAP1 Protein - NBP1-99222 from Novus Biologicals Category Protein Prices $299.00 Sizes 10 µg Species Human

TRAP1-Antibody-C-term-Blocking-peptide - BP14128b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human FLJ20113 protein - orb245184 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

TGFBRAP1 protein (His tag) - 80R-3721 from Fitzgerald Category Protein Prices $275.00 Sizes 50 µg Source E.coli

TRAP1 Blocking Peptide - 33R-8166 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TRAP1 protein - 30R-2887 from Fitzgerald Category Protein Prices $225.00 Sizes 10 µg Source E.coli

TRAP1 / HSP75 - H00010131-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

TRAP1 / HSP75 - H00010131-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

TRAP1 fusion protein - ag0400 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human TRAP1, FLAG-tagged - TRAP1-8462H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human TRAP1, His-tagged - TRAP1-2862H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Heat Shock Protein 75kDa, Mitochondrial (HSP75) - RPD525Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Heat Shock Protein 75kDa, Mitochondrial (HSP75) - RPD525Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant human Heat shock protein 75 kDa, mitochondrial protein - CSB-EP036044h CSB-BP036044h CSB-MP036044h from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Heat shock protein 75 kDa, mitochondrial(TRAP1) - CSB-YP618639HU CSB-EP618639HU CSB-BP618639HU CSB-MP618639HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Heat shock protein 75 kDa, mitochondrial(TRAP1),partial - CSB-RP036044h from Cusabio Category Protein Source E.coli Species Human

TNF Receptor-Associated Protein 1 (TRAP1), human recombinant - 7778-10 from Biovision Category Protein Prices $175.00 Sizes 10 μg Source E. coli. Species Human

TRAP-1 (510-860) - sc-4502 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Human

TRAP1 Recombinant Protein Antigen - NBP2-47598PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TRAP1 Protein - NBP2-47597PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

TRAP1 Peptide, Human - M34GP16530H from Creative Peptides Category Peptide Source Synthetic. Species Human

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