TRAP1

Gene Symbol TRAP1
Entrez Gene 10131
Alt Symbol HSP 75, HSP75, HSP90L, TRAP-1
Species Human
Gene Type protein-coding
Description TNF receptor-associated protein 1
Other Description TNFR-associated protein 1|heat shock protein 75 kDa, mitochondrial|tumor necrosis factor type 1 receptor-associated protein
Swissprots Q9UHL5 F5H897 B4DR68 D3DUC8 O75235 O43642 Q12931
Accessions AAC24722 EAW85338 EAW85339 EAW85340 EAW85341 EAW85342 Q12931 AB209805 BAD93042 AF043254 AAC02679 AF154108 AAF15314 AJ890085 CAI64498 AK057620 BAG51942 AK093344 BAC04139 AK223049 BAD96769 AK223076 BAD96796 AK223205 BAD96925 AK299127 BAG61180 BC000406 BC001455 AAH01455 BC002994 BC018950 AAH18950 BC023585 AAH23585 DB452880 DQ893476 ABM84402 DQ896346 ABM87345 JX481354 AFS69159 U12595 AAA87704 XM_011522345 XP_011520647 NM_001272049 NP_001258978 NM_016292 NP_057376
Function Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:23564345}. Mitochondrion inner membrane {ECO:0000269|PubMed:23564345}. Mitochondrion matrix {ECO:0000269|PubMed:23564345}.
Tissue Specificity Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is higly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors. {ECO:0000269|PubMed:23564345}.

TRAP1/HSP75 Antibody - 13405 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HCT 116 and U-87 MG cells using TRAP1/HSP75 Antibody (upper) and α-Actinin (D6F6) XP ® Rabbit mAb #6487 (lower).

HSP 75 (TR-1A) - sc-73604 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HSP 75 (TR-1A): sc-73604. Western blot analysis of HSP 75 expression in HL-60 whole cell lysate.

HSP 75 (H-123) - sc-366084 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
HSP 75 (H-123): sc-366084. Western blot analysis of HSP 75 expression in Hep G2 (A), HeLa (B), HL-60 (C) and K-562 (D) whole cell lysates.

HSP 75 (T-19) - sc-69289 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

HSP 75 (TR1) - sc-13557 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TRAP1 (TR1): sc-13557. Western blot analysis of TRAP1 expression in HL-60 (A), A-673 (B), SJR-H30 (C) and MIA PaCa-2 (D) whole cell lysates.

HSP 75 (C-18) - sc-69286 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HSP 75 (C-18): sc-69286. Western blot analysis of HSP 75 expression in MIA PaCa-2 (A) and K-562 (B) whole cell lysates.

HSP 75 (F-7) - sc-390061 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HSP 75 (F-7): sc-390061. Western blot analysis of HSP 75 expression in MIA PaCa-2 (A) and A-673 (B) whole cell lysates.

HSP 75 (30) - sc-136421 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HSP 75 (30): sc-136421. Western blot analysis of HSP 75 expression in HeLa whole cell lysate.

HSP 75 (42) - sc-135944 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/500 µl
Host Mouse
Clonality Monoclonal
HSP 75 (42): sc-135944. Western blot analysis of HSP 75 expression in HeLa whole cell lysate.

HSP 75 (B-23) - sc-133678 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
HSP 75 (B-23): sc-133678. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human kidney tissue showing cytoplasmic localization.

Anti-Hsp75 antibody - ab182775 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Hsp75 antibody (ab182775) at 1/1050 dilutionLane 1 : K562 cell lysateLane 2 : Jurkat cell lysateLane 3 : 293T cell lysateLysates/proteins at 30 µg per lane.SecondaryGoat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution

Anti-Hsp75 antibody [1A1] - ab119398 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1A1
Overlay histogram showing HepG2 cells stained with ab119398 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab119398, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-Hsp75 antibody [EPR5382] - ab128914 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5382
All lanes : Anti-Hsp75 antibody [EPR5382] (ab128914) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : 293T cell lysateLane 3 : Hela cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled Goat anti-Rabbit IgG at 1/2000 dilution

Anti-TRAP1 antibody - ab26135 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Ab26135 at a concentration of 4-8 µg/ml staining Paraffin Embedded Human Kidney cells by Immunohistochemistry. Cells with Positive label: Epithelial cells of renal tubule (Indicated with Arrows). Magnification:400x

Anti-TRAP1 antibody - ab116330 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TRAP1 antibody (ab116330) at 1/100 dilution + NCI-H460 cell line lysate at 35 µg

Anti-TRAP1 antibody [EPR5381] - ab109323 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5381
All lanes : Anti-TRAP1 antibody [EPR5381] (ab109323) at 1/10000 dilutionLane 1 : K562 cell lysateLane 2 : HL60 cell lysateLane 3 : 293T cell lysateLane 4 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-TRAP1 antibody [TRAP1-6] - ab2721 from Abcam

Prices $390.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone TRAP1-6
ab2721 staining TRAP1 in NCI-H460 cells by Immunocytochemistry/Immunofluorescence. Cells were grown on chamber slides and fixed with formaldehyde. Cells were probed without (right) or primary antibody (left) at a dilution of 1:200 overnight at 4 C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody. Green - TRAP1, Red (phalloidin) - F-actin, Blue (DAPI) - nuclei. Images were taken at 60X magnification.

Anti-TRAP1 / HSP75 Antibody (aa41-90) - LS-C31383 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
TRAP1 antibody LS-C31383 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-TRAP1 / HSP75 Antibody (aa37-86) - LS-C151176 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TRAP1 / HSP75 antibody Western Blot of HeLa.

Anti-TRAP1 / HSP75 Antibody (aa37-86) - LS-C82021 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.

Anti-TRAP1 / HSP75 Antibody (Internal, clone EPR5382) - LS-C152256 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5382
Western blot analysis on (A) K562, (B) 293T, and (C) HeLa cell lysates using anti-TRAP1 antibody.

Anti-TRAP1 / HSP75 Antibody (aa1-59) - LS-C209579 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TRAP1 / HSP75 Antibody (clone SPM178) - LS-C189448 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone SPM178

Anti-TRAP1 / HSP75 Antibody (clone Trap1-6, Atto 565) - LS-C227509 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone Trap1-6

Anti-TRAP1 / HSP75 Antibody (clone Trap1-6, Atto 594) - LS-C227510 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone Trap1-6
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