| Gene Symbol |
VPS4B
|
| Entrez Gene |
9525
|
| Alt Symbol |
MIG1, SKD1, SKD1B, VPS4-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
vacuolar protein sorting 4 homolog B (S. cerevisiae)
|
| Other Description |
cell migration-inducing 1|cell migration-inducing gene 1 protein|suppressor of K(+) transport growth defect 1|suppressor of K+ transport defect 1|vacuolar protein sorting 4B|vacuolar protein sorting-associated protein 4B
|
| Swissprots |
Q9GZS7 Q69HW4 O75351
|
| Accessions |
AAG01471 EAW63143 EAW63144 O75351 AF038960 AAC39874 AF195514 AAG33022 AK290932 BAF83621 AK291253 BAF83942 AK308892 AK309322 AK311041 AY232629 AAP59551 BC009692 AAH09692 BC039574 AAH39574 DA306069 EU831666 ACE87266 EU831748 ACE86582 HQ448561 ADQ33040 XM_006722582 XP_006722645 XM_011526268 XP_011524570 XR_935266 XR_935267 NM_004869 NP_004860
|
| Function |
Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:11563910, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:18687924}.
|
| Subcellular Location |
Prevacuolar compartment membrane; Peripheral membrane protein. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Membrane-associated in the prevacuolar endosomal compartment. Localized in HIV-1 particles purified from acutely infected cells.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:11563910}.
|
| Top Pathways |
Endocytosis
|