VPS4B

Gene Symbol VPS4B
Entrez Gene 9525
Alt Symbol MIG1, SKD1, SKD1B, VPS4-2
Species Human
Gene Type protein-coding
Description vacuolar protein sorting 4 homolog B (S. cerevisiae)
Other Description cell migration-inducing 1|cell migration-inducing gene 1 protein|suppressor of K(+) transport growth defect 1|suppressor of K+ transport defect 1|vacuolar protein sorting 4B|vacuolar protein sorting-associated protein 4B
Swissprots Q9GZS7 Q69HW4 O75351
Accessions AAG01471 EAW63143 EAW63144 O75351 AF038960 AAC39874 AF195514 AAG33022 AK290932 BAF83621 AK291253 BAF83942 AK308892 AK309322 AK311041 AY232629 AAP59551 BC009692 AAH09692 BC039574 AAH39574 DA306069 EU831666 ACE87266 EU831748 ACE86582 HQ448561 ADQ33040 XM_006722582 XP_006722645 XM_011526268 XP_011524570 XR_935266 XR_935267 NM_004869 NP_004860
Function Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:11563910, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:18687924}.
Subcellular Location Prevacuolar compartment membrane; Peripheral membrane protein. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Membrane-associated in the prevacuolar endosomal compartment. Localized in HIV-1 particles purified from acutely infected cells.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:11563910}.
Top Pathways Endocytosis

Human-VPS4B-cDNA-Clone - DC07280 from Abgent, a WuXi AppTec company

Prices $599.40
Sizes 10 µg
Species Human
Accession BC039574

VPS4B - MBS1271248 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC039574

Human VPS4B cDNA clone(NM_004869.3) - CDFH021134 from Creative Biomart

Species Human
Accession NM_004869.3

Human VPS4B ORF Clone(NM_004869.3) - CDCR289042 from Creative Biomart

Species Human
Accession NM_004869.3

Human VPS4B ORF Clone(NM_004869.3) - CDCR289043 from Creative Biomart

Species Human
Accession NM_004869.3

Human VPS4B ORF Clone(NM_004869.3) - CDCR289044 from Creative Biomart

Species Human
Accession NM_004869.3

Human VPS4B ORF Clone(NM_004869.3) - CDCL180995 from Creative Biomart

Species Human
Accession NM_004869.3

human VPS4B ORF clone - CDCH100254 from Creative Biomart

Species Human
Accession NM_004869

human VPS4B ORF clone - CDCH100255 from Creative Biomart

Species Human
Accession NM_004869

human VPS4B ORF clone - CDCH100256 from Creative Biomart

Species Human
Accession NM_004869

human VPS4B ORF clone - CDCH100257 from Creative Biomart

Species Human
Accession NM_004869

human VPS4B ORF clone (NM_004869.3) - CDCH100254 from Creative biogene

Species Human

Human VPS4B ORF Clone (BC039574) - CDCS411998 from Creative biogene

Species Human
Accession O75351

Human VPS4B cDNA Clone(NM_004869.3) - CDFH021134 from Creative biogene

Species Human
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