VPS4B

Gene Symbol	VPS4B
Entrez Gene	9525
Alt Symbol	MIG1, SKD1, SKD1B, VPS4-2
Species	Human
Gene Type	protein-coding
Description	vacuolar protein sorting 4 homolog B (S. cerevisiae)
Other Description	cell migration-inducing 1|cell migration-inducing gene 1 protein|suppressor of K(+) transport growth defect 1|suppressor of K+ transport defect 1|vacuolar protein sorting 4B|vacuolar protein sorting-associated protein 4B
Swissprots	Q9GZS7 Q69HW4 O75351
Accessions	AAG01471 EAW63143 EAW63144 O75351 AF038960 AAC39874 AF195514 AAG33022 AK290932 BAF83621 AK291253 BAF83942 AK308892 AK309322 AK311041 AY232629 AAP59551 BC009692 AAH09692 BC039574 AAH39574 DA306069 EU831666 ACE87266 EU831748 ACE86582 HQ448561 ADQ33040 XM_006722582 XP_006722645 XM_011526268 XP_011524570 XR_935266 XR_935267 NM_004869 NP_004860
Function	Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:11563910, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:18687924}.
Subcellular Location	Prevacuolar compartment membrane; Peripheral membrane protein. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Membrane-associated in the prevacuolar endosomal compartment. Localized in HIV-1 particles purified from acutely infected cells.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:11563910}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human VPS4B full length protein - ab132879 from Abcam Category Protein Source Wheat germ Species Human

Human VPS4B full length protein - ab171483 from Abcam Category Protein Source E. coli Species Human

VPS4B peptide - ab90848 from Abcam Category Peptide

SKD1 / VPS4B Antibody Blocking Peptide - LS-E2727 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SKD1 / VPS4B Antibody Blocking Peptide - LS-E22522 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

VPS4B Recombinant Protein - H00009525-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human VPS4B Protein - NBP2-22937 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E.coli Species Human

VPS4B-Antibody-C-term-Blocking-peptide - BP13813b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human VPS4B protein - orb191368 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

VPS4B Blocking Peptide - 33R-10320 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

VPS4B protein (His tag) - 80R-3485 from Fitzgerald Category Protein Prices $365.00 Sizes 50 µg Source E.coli

VPS4B (1-444, His-tag) - AR51176PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

VPS4B (1-444, His-tag) - AR51176PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

VPS4B - H00009525-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

VPS4B - H00009525-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

VPS4B, 1-444aa, Human, His tag, E.coli - 01-P2352 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

VPS4B fusion protein - Ag11610 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

VPS4B fusion protein - Ag11583 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human VPS4B, His-tagged - VPS4B-3683H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human vacuolar protein sorting 4 homolog B (S. cerevisiae), His-tagged - VPS4B-269H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Vacuolar protein sorting-associated protein 4B(VPS4B) - CSB-YP025915HU CSB-EP025915HU CSB-BP025915HU CSB-MP025915HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

VPS4B - TP308019 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

VPS4B, 1-444aa, Human, His tag, E.coli - ATGP2352 from ATGen Category Protein Prices $105.00, $320.00, $960.00 Sizes 10 µg, 50 µg, 250 µg Species Human

Vacuolar Protein Sorting 4 Homolog B, Recombinant Protein - MBS145696 from MyBioSource Category Protein Prices $140.00, $205.00, $4,975.00 Sizes 2 µg, 10 µg, 1 mg Source E Coli

Vacuolar protein sorting-associated protein 4B(VPS4B) , Recombinant Protein - MBS1197224 from MyBioSource Category Protein Prices $1,985.00, $1,985.00, $2,445.00, $2,445.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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