SOCS2

Gene Symbol SOCS2
Entrez Gene 8835
Alt Symbol CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2
Species Human
Gene Type protein-coding
Description suppressor of cytokine signaling 2
Other Description CIS-2|STAT induced STAT inhibitor-2|STAT-induced STAT inhibitor 2|STAT-induced STAT inhibitor-2|cytokine-inducible SH2 protein 2|suppressor of cytokine signaling-2
Swissprots O14508 O95102 Q9UKS5 O14542 A8K3D1
Accessions AAD27710 EAW97492 EAW97493 O14508 AB004903 BAA22429 AB006966 BAA22536 AB451318 BAG70132 AF020590 AAC98896 AF037989 AAC34745 AI129818 AK290546 BAF83235 AK297662 BAG60027 AK309452 AK313165 BAG35983 AL161980 AL522912 BC010399 AAH10399 BC070039 BJ996504 CD699665 DA490057 DA709082 DB054162 DB481261 DC300183 XM_005269213 XP_005269270 XM_006719673 XP_006719736 XM_006719674 XP_006719737 XM_011538929 XP_011537231 XM_011538930 XP_011537232 XM_011538931 XP_011537233 XM_011538932 XP_011537234 XM_011538933 XP_011537235 XM_011538934 XP_011537236 XM_011538935 XP_011537237 XM_011538936 XP_011537238 XR_944810 NM_001270467 NP_001257396 NM_001270468 NP_001257397 NM_001270469 NP_001257398 NM_001270470 NP_001257399 NM_001270471 NP_001257400 NM_003877 NP_003868
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Tissue Specificity High expression in heart, placenta, lung, kidney and prostate.
Top Pathways Jak-STAT signaling pathway, Insulin signaling pathway, Type II diabetes mellitus, Prolactin signaling pathway

SOCS2 Antibody - 2779 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from K562, A204 and PC12 cells using SOCS2 Antibody.

SOCS-2 (H-74) - sc-9022 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SOCS-2 (H-74): sc-9022. Immunoperoxidase staining of formalin fixed, paraffin-embedded human endometrium tissue showing cytoplasmic staining of glandular cells, cells in myometrum and endometrial stroma at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

SOCS-2 (L-19) - sc-7008 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SOCS-2 (M-19) - sc-7007 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SOCS2 antibody - ab3692 from Abcam

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SOCS2 antibody [EPR2588(2)] - ab109245 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2588(2)
Immunofluorescent staining of HeLa cells using ab109245 at 1/100 dilution.

Anti-SOCS2 antibody - ab92847 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of SOCS2 staining in human lung formalin fixed paraffin embedded tissue section, performed on a Leica Bond system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab92847, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-SOCS2 antibody - ab74533 from Abcam

Prices $378.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab74533 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab74533, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-SOCS2 antibody - Carboxyterminal end, prediluted - ab53186 from Abcam

Prices $370.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal

Anti-SOCS2 Antibody - LS-C132149 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SOCS2 Antibody (aa181-198, Magnetic beads) - LS-C172301 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SOCS2 Antibody (aa181-198) - LS-C172300 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SOCS2 Antibody (aa181-198, Sepharose) - LS-C172302 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SOCS2 Antibody (C-Terminus) - LS-C50492 from LifeSpan Bioscience

Prices $530.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of Human Pancreas stained with anti-SOCS-2 antibody

Anti-SOCS2 Antibody (C-Terminus) - LS-C182445 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SOCS2 Antibody (Internal) - LS-C209734 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-SOCS2 Antibody (aa117-166) - LS-C146248 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SOCS2 antibody LS-C146248 Western blot of U937 Cell lysate. Antibody concentration 1 ug/ml.

Anti-SOCS2 Antibody (Glu67) - LS-C177268 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of SOCS-2 (E67) pAb in extracts from Jurkat cells.

Anti-SOCS2 Antibody (aa18-67) - LS-C200007 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of SOCS-2 antibody in extracts from Jurkat cells.

Anti-SOCS2 Antibody (N-Terminus, clone EPR2588(2)) - LS-C138153 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2588(2)
Immunofluorescent staining of HeLa cells using anti-SOCS2 antibody.

Anti-SOCS2 Antibody IHC-plus™ - LS-B1257 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SOCS2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1257 concentration 20 ug/ml.

SOCS-2 Antibody (517206) - MAB4979 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 517206

SOCS-2 Antibody - AF4979 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of K562 human chronic myelogenous leukemia cell line. Gels were loaded with 30 μg of whole cell lysate (WCL), 20 μg of cytoplasmic (Cyto), and 10 μg of nuclear extracts (Nuc). PVDF membrane was probed with 0.1 µg/mL Goat Anti-Human SOCS‑2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4979) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band for SOCS‑2 was detected at approximately 25 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

SOCS-2 Antibody - NB600-1338 from Novus Biologicals

Prices $279.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: SOCS2 Antibody [NB600-1338] - Western blot analysis of the Hela cell lysate with the anti-SOCS2.

SOCS-2 Antibody - NBP1-51218 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: SOCS2 Antibody [NBP1-51218] Extracts from Jurkat cells
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