| Gene Symbol |
SOCS2
|
| Entrez Gene |
8835
|
| Alt Symbol |
CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
suppressor of cytokine signaling 2
|
| Other Description |
CIS-2|STAT induced STAT inhibitor-2|STAT-induced STAT inhibitor 2|STAT-induced STAT inhibitor-2|cytokine-inducible SH2 protein 2|suppressor of cytokine signaling-2
|
| Swissprots |
O14508 O95102 Q9UKS5 O14542 A8K3D1
|
| Accessions |
AAD27710 EAW97492 EAW97493 O14508 AB004903 BAA22429 AB006966 BAA22536 AB451318 BAG70132 AF020590 AAC98896 AF037989 AAC34745 AI129818 AK290546 BAF83235 AK297662 BAG60027 AK309452 AK313165 BAG35983 AL161980 AL522912 BC010399 AAH10399 BC070039 BJ996504 CD699665 DA490057 DA709082 DB054162 DB481261 DC300183 XM_005269213 XP_005269270 XM_006719673 XP_006719736 XM_006719674 XP_006719737 XM_011538929 XP_011537231 XM_011538930 XP_011537232 XM_011538931 XP_011537233 XM_011538932 XP_011537234 XM_011538933 XP_011537235 XM_011538934 XP_011537236 XM_011538935 XP_011537237 XM_011538936 XP_011537238 XR_944810 NM_001270467 NP_001257396 NM_001270468 NP_001257397 NM_001270469 NP_001257398 NM_001270470 NP_001257399 NM_001270471 NP_001257400 NM_003877 NP_003868
|
| Function |
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
|
| Tissue Specificity |
High expression in heart, placenta, lung, kidney and prostate.
|
| Top Pathways |
Jak-STAT signaling pathway, Insulin signaling pathway, Type II diabetes mellitus, Prolactin signaling pathway
|
![Western Blot: SOCS2 Overexpression Lysate (Adult Normal) [NBL1-16326] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SOCS2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3490_SOCS2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16326-img0002.jpg)