Gene Symbol | TXNRD3 |
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Entrez Gene | 114112 |
Alt Symbol | TGR, TR2, TRXR3 |
Species | Human |
Gene Type | protein-coding |
Description | thioredoxin reductase 3 |
Other Description | thioredoxin and glutathione reductase|thioredoxin glutathione reductase|thioredoxin reductase 2|thioredoxin reductase TR2 |
Swissprots | Q9NNW6 Q9P101 Q6PIS8 Q86VQ6 |
Accessions | Q86VQ6 AF133519 AAD39929 AF171055 AAD51325 AK299502 BAG61457 BC030028 AAH30028 BC050032 AAH50032 BQ929894 NM_001173513 NP_001166984 NM_052883 NP_443115 |
Function | Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity). {ECO:0000250|UniProtKB:Q99MD6}. |
Subcellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q99MD6}. Nucleus {ECO:0000250|UniProtKB:Q99MD6}. Microsome {ECO:0000250|UniProtKB:Q99MD6}. Endoplasmic reticulum {ECO:0000250}. Note=Detected in cytoplasm and nucleus in late spermatids. {ECO:0000250|UniProtKB:Q99MD6}. |
Top Pathways | Selenocompound metabolism, Pyrimidine metabolism |
Anti-TXNRD3 antibody - ab134034 from Abcam
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Anti-TXNRD3 Antibody (aa304-333, AP) - LS-C224557 from LifeSpan Bioscience
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Anti-TXNRD3 Antibody (aa304-333, APC) - LS-C224560 from LifeSpan Bioscience
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Anti-TXNRD3 Antibody (aa304-333, Biotin) - LS-C224561 from LifeSpan Bioscience
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Anti-TXNRD3 Antibody (aa304-333, PE) - LS-C224564 from LifeSpan Bioscience
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Anti-TXNRD3 Antibody (aa304-333, FITC) - LS-C224562 from LifeSpan Bioscience
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Anti-TXNRD3 Antibody (aa31-80) - LS-C151810 from LifeSpan Bioscience
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Anti-TXNRD3 Antibody (aa304-333, Azide-free, HRP) - LS-C224563 from LifeSpan Bioscience
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Anti-TXNRD3 Antibody (aa304-333) - LS-C326111 from LifeSpan Bioscience
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Anti-TXNRD3 Antibody (aa251-300) - LS-C151811 from LifeSpan Bioscience
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Anti-TXNRD3 Antibody (aa304-333) - LS-C157007 from LifeSpan Bioscience
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TRXR3 Antibody - NBP1-98287 from Novus Biologicals
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ANTI-TXNRD3 (CENTER) antibody produced in rabbit - SAB1305933 from Sigma-Aldrich
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TXNRD3 Antibody - N-terminal region (ARP64748_P050) - ARP64748_P050 from Aviva Systems Biology
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TXNRD3 antibody - middle region (ARP64749_P050) - ARP64749_P050 from Aviva Systems Biology
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TXNRD3-AntibodyCenter - AP19608c from Abgent, a WuXi AppTec company
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TXNRD3 Antibody - middle region (OAAB15135) - OAAB15135 from Aviva Systems Biology
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TXNRD3 Polyclonal Antibody - A3697 from ABclonal
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TXNRD3 Antibody - abx031109 from Abbexa
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TXNRD3 Antibody - abx002666 from Abbexa
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Thioredoxin reductase 3 antibody - 19517-1-AP from Acris Antibodies
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TXNRD3 antibody - STJ26453 from St John's Laboratory Ltd
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TXNRD3 antibody - 19517-1-AP from Proteintech Group
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TXNRD3 - A3697 from NeoScientific
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TXNRD3 Antibody - GWB-MX219C from Genway Biotech
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