| Gene Symbol |
TXNRD3
|
| Entrez Gene |
114112
|
| Alt Symbol |
TGR, TR2, TRXR3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
thioredoxin reductase 3
|
| Other Description |
thioredoxin and glutathione reductase|thioredoxin glutathione reductase|thioredoxin reductase 2|thioredoxin reductase TR2
|
| Swissprots |
Q9NNW6 Q9P101 Q6PIS8 Q86VQ6
|
| Accessions |
Q86VQ6 AF133519 AAD39929 AF171055 AAD51325 AK299502 BAG61457 BC030028 AAH30028 BC050032 AAH50032 BQ929894 NM_001173513 NP_001166984 NM_052883 NP_443115
|
| Function |
Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity). {ECO:0000250|UniProtKB:Q99MD6}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250|UniProtKB:Q99MD6}. Nucleus {ECO:0000250|UniProtKB:Q99MD6}. Microsome {ECO:0000250|UniProtKB:Q99MD6}. Endoplasmic reticulum {ECO:0000250}. Note=Detected in cytoplasm and nucleus in late spermatids. {ECO:0000250|UniProtKB:Q99MD6}.
|
| Top Pathways |
Selenocompound metabolism, Pyrimidine metabolism
|