Gene Symbol | TXNRD3 |
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Entrez Gene | 114112 |
Alt Symbol | TGR, TR2, TRXR3 |
Species | Human |
Gene Type | protein-coding |
Description | thioredoxin reductase 3 |
Other Description | thioredoxin and glutathione reductase|thioredoxin glutathione reductase|thioredoxin reductase 2|thioredoxin reductase TR2 |
Swissprots | Q9NNW6 Q9P101 Q6PIS8 Q86VQ6 |
Accessions | Q86VQ6 AF133519 AAD39929 AF171055 AAD51325 AK299502 BAG61457 BC030028 AAH30028 BC050032 AAH50032 BQ929894 NM_001173513 NP_001166984 NM_052883 NP_443115 |
Function | Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity). {ECO:0000250|UniProtKB:Q99MD6}. |
Subcellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q99MD6}. Nucleus {ECO:0000250|UniProtKB:Q99MD6}. Microsome {ECO:0000250|UniProtKB:Q99MD6}. Endoplasmic reticulum {ECO:0000250}. Note=Detected in cytoplasm and nucleus in late spermatids. {ECO:0000250|UniProtKB:Q99MD6}. |
Top Pathways | Selenocompound metabolism, Pyrimidine metabolism |
TXNRD3 Antibody Blocking Peptide - LS-E23610 from LifeSpan Bioscience
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TXNRD3 Antibody Blocking Peptide - LS-E23611 from LifeSpan Bioscience
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TXNRD3 Antibody Blocking Peptide - LS-E6738 from LifeSpan Bioscience
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TXNRD3-AntibodyCenter-Blocking-peptide - BP19608c from Abgent, a WuXi AppTec company
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Recombinant Human Thioredoxin reductase 3(TXNRD3) - CSB-YP025390HU CSB-EP025390HU CSB-BP025390HU CSB-MP025390HU from Cusabio
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Thioredoxin Reductase 2, Recombinant Protein - MBS5304000 from MyBioSource
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Thioredoxin Reductase 2, SelCys523Cys, Recombinant Protein - MBS637265 from MyBioSource
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Thioredoxin reductase 3 (TXNRD3), Recombinant Protein - MBS1442020 from MyBioSource
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TXNRD3 Peptide, Human - M34GP16908H from Creative Peptides
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TRXR3 Recombinant Protein Antigen - NBP2-55016PEP from Novus Biologicals
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