PLCL1

Gene Symbol PLCL1
Entrez Gene 5334
Alt Symbol PLCE, PLCL, PLDL1, PPP1R127, PRIP
Species Human
Gene Type protein-coding
Description phospholipase C-like 1
Other Description PLC-L1|inactive phospholipase C-like protein 1|phospholipase C related, but catalytically inactive protein|phospholipase C, epsilon|phospholipase C-deleted in lung carcinoma|phospholipase C-related but catalytically inactive protein|protein phosphatase 1, regulatory subunit 127
Swissprots Q15111 Q53SD3 Q7Z3S3 Q3MJ90
Accessions AAY14733 EAW70174 Q15111 AK127514 AK302673 BAG63906 BC101531 AAI01532 BC111985 AAI11986 BP340710 BX537442 CAD97684 D42108 BAA07688 DA193701 DA414853 T87219 XM_005246643 XP_005246700 XM_005246644 XP_005246701 XM_011511351 XP_011509653 NM_006226 NP_006217
Function Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a inhibitor of PPP1C. {ECO:0000250, ECO:0000269|PubMed:17254016}.
Subcellular Location Cytoplasm {ECO:0000250}.
Tissue Specificity Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain. {ECO:0000269|PubMed:16952428, ECO:0000269|PubMed:7633416}.
Top Pathways GABAergic synapse

PLC-L (D-5) - sc-28328 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PLC-L (D-5): sc-28328. Western blot analysis of PLC-L expression in mouse cerebellum (A) and rat brain (B) tissue extracts.

PLC-L (H-65) - sc-25502 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

PLC-L (V-20) - sc-17025 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PLCL1 antibody - ab93425 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PLCL1 antibody (ab93425) at 1/100 dilution + Jurkat cell line lysates at 35 µg

Anti-PLCL1 antibody [EPR11213] - ab157200 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11213
Western blot analysis of Immunoprecipitation pellet from Human fetal brain lysate showing PLCL1, using ab157200 at 1/10 dilution for IP.

Anti-PLCL1 Antibody IHC-plus™ - LS-B8903 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PLCL1 antibody IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-PLCL1 Antibody (N-Terminus, AP) - LS-C280883 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLCL1 Antibody (N-Terminus, APC) - LS-C280886 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLCL1 Antibody (N-Terminus, Biotin) - LS-C280887 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLCL1 Antibody (N-Terminus, FITC) - LS-C280888 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLCL1 Antibody (N-Terminus, Azide-free, HRP) - LS-C280890 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLCL1 Antibody (N-Terminus, PE) - LS-C280889 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLCL1 Antibody (N-Terminus) - LS-C328223 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLCL1 Antibody (aa149-176) - LS-C163778 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of PLCL1 Antibody in Jurkat cell line lysates (35 ug/lane). PLCL1 (arrow) was detected using the purified antibody.

Phospholipase C like 1 Antibody - NBP1-80896 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Phospholipase C like 1 Antibody [NBP1-80896] - Staining of human kidney shows strong cytoplasmic positivity, with a granular pattern in renal tubule cells.

PLCL1 Polyclonal Antibody - bs-4151R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded mouse brain labeled with Rabbit Anti-PLDL1 Polyclonal Antibody, Unconjugated (bs-4151R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-PLCL1 antibody produced in rabbit - HPA031849 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PLCL1: <B>Cat. No. HPA031849</B>: Immunohistochemical staining of human kidney shows strong cytoplasmic positivity, with a granular pattern in renal tubular cells.

ANTI-PLCL1 (N-TERM) antibody produced in rabbit - SAB1303872 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

PLCL1-Antibody-N-term - AP8850a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of PLCL1 Antibody (N-term) (Cat. #AP8850a) in Jurkat cell line lysates (35ug/lane). PLCL1 (arrow) was detected using the purified Pab.

PLCL1 Antibody - N-terminal region (OAAB05445) - OAAB05445 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

PLDL1 antibody - orb4486 from Biorbyt

Prices $255.00, $340.00
Sizes 100 μg, 200 μg
Host Rabbit
Clonality Polyclonal
Immunohistochemical staining of Mouse brain tissue using PLDL1 antibody.

PLCL1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-4151R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PLCL1 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-4151R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PLCL1 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-4151R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PLCL1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-4151R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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