PLCL1

Gene Symbol	PLCL1
Entrez Gene	5334
Alt Symbol	PLCE, PLCL, PLDL1, PPP1R127, PRIP
Species	Human
Gene Type	protein-coding
Description	phospholipase C-like 1
Other Description	PLC-L1|inactive phospholipase C-like protein 1|phospholipase C related, but catalytically inactive protein|phospholipase C, epsilon|phospholipase C-deleted in lung carcinoma|phospholipase C-related but catalytically inactive protein|protein phosphatase 1, regulatory subunit 127
Swissprots	Q15111 Q53SD3 Q7Z3S3 Q3MJ90
Accessions	AAY14733 EAW70174 Q15111 AK127514 AK302673 BAG63906 BC101531 AAI01532 BC111985 AAI11986 BP340710 BX537442 CAD97684 D42108 BAA07688 DA193701 DA414853 T87219 XM_005246643 XP_005246700 XM_005246644 XP_005246701 XM_011511351 XP_011509653 NM_006226 NP_006217
Function	Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a inhibitor of PPP1C. {ECO:0000250, ECO:0000269|PubMed:17254016}.
Subcellular Location	Cytoplasm {ECO:0000250}.
Tissue Specificity	Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain. {ECO:0000269|PubMed:16952428, ECO:0000269|PubMed:7633416}.
Top Pathways	GABAergic synapse

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Inactive phospholipase C-like protein 1 (PLCL1), Human, ELISA Kit - CSB-EL018138HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

phospholipase C-like 1, ELISA Kit - MBS922790 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human PLCL1 is typically less than 11.7 pg/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 46.88 pg/ml -3000 pg/ml.

Human Inactive phospholipase C-like protein 1(PLCL1) ELISA kit - CSB-EL018138HU from Cusabio Category ELISA Kit Sensitivity 11.7 pg/ml Range 46.88 pg/ml-3000 pg/ml

Human PLCL1 ELISA Kit - E029221 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human PLCL1 is typically less than 11.7 pg/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mea

PLCL1 ELISA Kit (Human) (OKCA00698) - OKCA00698 from Aviva Systems Biology Category ELISA Kit Prices $590.00 Sizes 96 wells Sensitivity 11.7 pg/mL Range 46.88 pg/mL-3,000 pg/mL

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