| Gene Symbol |
PLCL1
|
| Entrez Gene |
5334
|
| Alt Symbol |
PLCE, PLCL, PLDL1, PPP1R127, PRIP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phospholipase C-like 1
|
| Other Description |
PLC-L1|inactive phospholipase C-like protein 1|phospholipase C related, but catalytically inactive protein|phospholipase C, epsilon|phospholipase C-deleted in lung carcinoma|phospholipase C-related but catalytically inactive protein|protein phosphatase 1, regulatory subunit 127
|
| Swissprots |
Q15111 Q53SD3 Q7Z3S3 Q3MJ90
|
| Accessions |
AAY14733 EAW70174 Q15111 AK127514 AK302673 BAG63906 BC101531 AAI01532 BC111985 AAI11986 BP340710 BX537442 CAD97684 D42108 BAA07688 DA193701 DA414853 T87219 XM_005246643 XP_005246700 XM_005246644 XP_005246701 XM_011511351 XP_011509653 NM_006226 NP_006217
|
| Function |
Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a inhibitor of PPP1C. {ECO:0000250, ECO:0000269|PubMed:17254016}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain. {ECO:0000269|PubMed:16952428, ECO:0000269|PubMed:7633416}.
|
| Top Pathways |
GABAergic synapse
|