PLCL1

Gene Symbol PLCL1
Entrez Gene 5334
Alt Symbol PLCE, PLCL, PLDL1, PPP1R127, PRIP
Species Human
Gene Type protein-coding
Description phospholipase C-like 1
Other Description PLC-L1|inactive phospholipase C-like protein 1|phospholipase C related, but catalytically inactive protein|phospholipase C, epsilon|phospholipase C-deleted in lung carcinoma|phospholipase C-related but catalytically inactive protein|protein phosphatase 1, regulatory subunit 127
Swissprots Q15111 Q53SD3 Q7Z3S3 Q3MJ90
Accessions AAY14733 EAW70174 Q15111 AK127514 AK302673 BAG63906 BC101531 AAI01532 BC111985 AAI11986 BP340710 BX537442 CAD97684 D42108 BAA07688 DA193701 DA414853 T87219 XM_005246643 XP_005246700 XM_005246644 XP_005246701 XM_011511351 XP_011509653 NM_006226 NP_006217
Function Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a inhibitor of PPP1C. {ECO:0000250, ECO:0000269|PubMed:17254016}.
Subcellular Location Cytoplasm {ECO:0000250}.
Tissue Specificity Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain. {ECO:0000269|PubMed:16952428, ECO:0000269|PubMed:7633416}.
Top Pathways GABAergic synapse

PLC-L CRISPR/Cas9 KO Plasmid (h) - sc-410941 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLC-L HDR Plasmid (h) - sc-410941-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLC-L Double Nickase Plasmid (h) - sc-410941-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLC-L Double Nickase Plasmid (h2) - sc-410941-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLC-L CRISPR Activation Plasmid (h) - sc-410941-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLC-L CRISPR Activation Plasmid (h2) - sc-410941-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLC-L Lentiviral Activation Particles (h) - sc-410941-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLC-L Lentiviral Activation Particles (h2) - sc-410941-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLC-L siRNA (h) - sc-40845 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PLC-L shRNA Plasmid (h) - sc-40845-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PLC-L shRNA (h) Lentiviral Particles - sc-40845-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Phospholipase C like 1 RNAi - H00005334-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU143431 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16930 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16930 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09643 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09643

PLCL1 siRNA (Human) - CRH3574 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PLCL1 (NM_006226.3) - SHH377264 from Creative biogene

Category siRNA
Species Reactivities Human

Human PLCL1 siRNA - orb264076 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PLCL1 shRNA Plasmid (Human) - CHH3574 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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