| Gene Symbol |
UQCC2
|
| Entrez Gene |
84300
|
| Alt Symbol |
C6orf125, Cbp6, M19, MNF1, bA6B20.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquinol-cytochrome c reductase complex assembly factor 2
|
| Other Description |
breast cancer-associated protein SGA-81M|cytochrome B protein synthesis 6 homolog|mitochondrial nucleoid factor 1|mitochondrial protein M19|ubiquinol-cytochrome-c reductase complex assembly factor 2
|
| Swissprots |
Q9BRT2 B2R4I0
|
| Accessions |
EAX03745 Q9BRT2 AF086234 AI688269 AK127468 AK311835 BAG34777 AY568085 AAS68365 BC006007 AAH06007 BI604191 CB241659 CN261727 DA123098 EF139858 NM_032340 NP_115716
|
| Function |
Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells. Involved in cytochrome b translation and/or stability. {ECO:0000269|PubMed:22363741, ECO:0000269|PubMed:24385928}.
|
| Subcellular Location |
Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion. Mitochondrion intermembrane space {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Mitochondrion inner membrane {ECO:0000250}. Note=Predominantly expressed in the mitochondrial inner membrane. {ECO:0000250}.
|
| Tissue Specificity |
Pancreas, skeletal muscle, kidney, liver and heart. {ECO:0000269|PubMed:22363741}.
|
![Western Blot: C6orf125 Overexpression Lysate (Adult Normal) [NBL1-08511] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for C6orf125.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7116_C6orf125%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08511-img0002.jpg)