Gene Symbol | UQCC2 |
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Entrez Gene | 84300 |
Alt Symbol | C6orf125, Cbp6, M19, MNF1, bA6B20.2 |
Species | Human |
Gene Type | protein-coding |
Description | ubiquinol-cytochrome c reductase complex assembly factor 2 |
Other Description | breast cancer-associated protein SGA-81M|cytochrome B protein synthesis 6 homolog|mitochondrial nucleoid factor 1|mitochondrial protein M19|ubiquinol-cytochrome-c reductase complex assembly factor 2 |
Swissprots | Q9BRT2 B2R4I0 |
Accessions | EAX03745 Q9BRT2 AF086234 AI688269 AK127468 AK311835 BAG34777 AY568085 AAS68365 BC006007 AAH06007 BI604191 CB241659 CN261727 DA123098 EF139858 NM_032340 NP_115716 |
Function | Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells. Involved in cytochrome b translation and/or stability. {ECO:0000269|PubMed:22363741, ECO:0000269|PubMed:24385928}. |
Subcellular Location | Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion. Mitochondrion intermembrane space {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Mitochondrion inner membrane {ECO:0000250}. Note=Predominantly expressed in the mitochondrial inner membrane. {ECO:0000250}. |
Tissue Specificity | Pancreas, skeletal muscle, kidney, liver and heart. {ECO:0000269|PubMed:22363741}. |
C6orf125 CRISPR/Cas9 KO Plasmid (h) - sc-413619 from Santa Cruz Biotechnology
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C6orf125 HDR Plasmid (h) - sc-413619-HDR from Santa Cruz Biotechnology
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C6orf125 Double Nickase Plasmid (h) - sc-413619-NIC from Santa Cruz Biotechnology
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C6orf125 Double Nickase Plasmid (h2) - sc-413619-NIC-2 from Santa Cruz Biotechnology
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C6orf125 CRISPR Activation Plasmid (h) - sc-413619-ACT from Santa Cruz Biotechnology
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C6orf125 CRISPR Activation Plasmid (h2) - sc-413619-ACT-2 from Santa Cruz Biotechnology
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C6orf125 Lentiviral Activation Particles (h) - sc-413619-LAC from Santa Cruz Biotechnology
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C6orf125 Lentiviral Activation Particles (h2) - sc-413619-LAC-2 from Santa Cruz Biotechnology
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C6orf125 siRNA (h) - sc-95354 from Santa Cruz Biotechnology
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C6orf125 shRNA Plasmid (h) - sc-95354-SH from Santa Cruz Biotechnology
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C6orf125 shRNA (h) Lentiviral Particles - sc-95354-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU006491 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5019 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5019 from Sigma-Aldrich
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UQCC2 siRNA (Human) - CRJ3423 from Cohesion Biosciences
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UQCC2 - MBS8206373 from MyBioSource
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shRNA set against Human C6orf125 (NM_032340.3) - SHH252189 from Creative biogene
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Human UQCC2 siRNA - orb273924 from Biorbyt
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UQCC2 shRNA Plasmid (Human) - CHJ3423 from Cohesion Biosciences
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MNF1 miRNA 3'UTR clone - MiUTR3H-13259 from Creative biogene
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