| Gene Symbol |
DTD1
|
| Entrez Gene |
92675
|
| Alt Symbol |
C20orf88, DUE-B, DUEB, HARS2, bA379J5.3, bA555E18.1, pqn-68
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
D-tyrosyl-tRNA deacylase 1
|
| Other Description |
D-tyrosyl-tRNA deacylase 1 homolog|D-tyrosyl-tRNA(Tyr) deacylase 1|DNA-unwinding element-binding protein B|histidyl-tRNA synthase-related|histidyl-tRNA synthetase 2
|
| Swissprots |
Q9H464 Q5W184 Q8WXU8 A8K5X5 Q8TEA8 D3DW37 Q9H474 Q496D1 Q9BW67
|
| Accessions |
EAX10227 EAX10228 Q8TEA8 AF332356 AAL57046 AK074304 BAB85044 AK291440 BAF84129 BC000599 BC045167 AAH45167 BC100923 AAI00924 BC100924 AAI00925 BC100925 AAI00926 BC100926 AAI00927 BI465352 BU729150 DB550292 HQ447971 ADQ32454 XM_005260871 XP_005260928 XM_005260872 XP_005260929 NM_080820 NP_543010
|
| Function |
ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes. May hydrolyze D- tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr), a possible defense mechanism against a harmful effect of D-tyrosine. {ECO:0000269|PubMed:15653697, ECO:0000269|PubMed:20065034}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15653697, ECO:0000269|PubMed:20065034}. Cytoplasm {ECO:0000305}. Note=Associated with chromatin at some replication origins containing functional DNA-unwinding elements.
|
| Tissue Specificity |
Expressed in many adult and fetal tissues. Highest levels in testis, ovary, spleen and in adult and fetal brain. {ECO:0000269|PubMed:12392168}.
|
![Western Blot: DTD1 Overexpression Lysate (Adult Normal) [NBL1-10030] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DTD1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7069_DTD1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10030-img0002.jpg)