Gene Symbol | DTD1 |
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Entrez Gene | 92675 |
Alt Symbol | C20orf88, DUE-B, DUEB, HARS2, bA379J5.3, bA555E18.1, pqn-68 |
Species | Human |
Gene Type | protein-coding |
Description | D-tyrosyl-tRNA deacylase 1 |
Other Description | D-tyrosyl-tRNA deacylase 1 homolog|D-tyrosyl-tRNA(Tyr) deacylase 1|DNA-unwinding element-binding protein B|histidyl-tRNA synthase-related|histidyl-tRNA synthetase 2 |
Swissprots | Q9H464 Q5W184 Q8WXU8 A8K5X5 Q8TEA8 D3DW37 Q9H474 Q496D1 Q9BW67 |
Accessions | EAX10227 EAX10228 Q8TEA8 AF332356 AAL57046 AK074304 BAB85044 AK291440 BAF84129 BC000599 BC045167 AAH45167 BC100923 AAI00924 BC100924 AAI00925 BC100925 AAI00926 BC100926 AAI00927 BI465352 BU729150 DB550292 HQ447971 ADQ32454 XM_005260871 XP_005260928 XM_005260872 XP_005260929 NM_080820 NP_543010 |
Function | ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes. May hydrolyze D- tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr), a possible defense mechanism against a harmful effect of D-tyrosine. {ECO:0000269|PubMed:15653697, ECO:0000269|PubMed:20065034}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:15653697, ECO:0000269|PubMed:20065034}. Cytoplasm {ECO:0000305}. Note=Associated with chromatin at some replication origins containing functional DNA-unwinding elements. |
Tissue Specificity | Expressed in many adult and fetal tissues. Highest levels in testis, ovary, spleen and in adult and fetal brain. {ECO:0000269|PubMed:12392168}. |
DUE-B CRISPR/Cas9 KO Plasmid (h) - sc-413949 from Santa Cruz Biotechnology
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DUE-B HDR Plasmid (h) - sc-413949-HDR from Santa Cruz Biotechnology
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DUE-B Double Nickase Plasmid (h) - sc-413949-NIC from Santa Cruz Biotechnology
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DUE-B Double Nickase Plasmid (h2) - sc-413949-NIC-2 from Santa Cruz Biotechnology
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DUE-B CRISPR Activation Plasmid (h) - sc-413949-ACT from Santa Cruz Biotechnology
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DUE-B CRISPR Activation Plasmid (h2) - sc-413949-ACT-2 from Santa Cruz Biotechnology
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DUE-B Lentiviral Activation Particles (h) - sc-413949-LAC from Santa Cruz Biotechnology
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DUE-B Lentiviral Activation Particles (h2) - sc-413949-LAC-2 from Santa Cruz Biotechnology
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DUE-B siRNA (h) - sc-77189 from Santa Cruz Biotechnology
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DUE-B shRNA Plasmid (h) - sc-77189-SH from Santa Cruz Biotechnology
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DUE-B shRNA (h) Lentiviral Particles - sc-77189-V from Santa Cruz Biotechnology
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HARS2 RNAi - H00023438-R01 from Novus Biologicals
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MISSION® esiRNA - EHU038701 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7519 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7519 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04481 from Sigma-Aldrich
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DTD1 siRNA (Human) - CRJ4155 from Cohesion Biosciences
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DTD1 - MBS829888 from MyBioSource
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shRNA set against Human DTD1 (NM_080820.4) - SHH281385 from Creative biogene
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Human DTD1 siRNA - orb274656 from Biorbyt
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DTD1 shRNA Plasmid (Human) - CHJ4155 from Cohesion Biosciences
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DTD1 miRNA 3'UTR clone - MiUTR1H-03016 from Creative biogene
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