LDLR

Gene Symbol	LDLR
Entrez Gene	3949
Alt Symbol	FH, FHC, LDLCQ2
Species	Human
Gene Type	protein-coding
Description	low density lipoprotein receptor
Other Description	LDL receptor|low-density lipoprotein receptor|low-density lipoprotein receptor class A domain-containing protein 3
Swissprots	H0YNT7 P01130 B4DII3 Q53ZD9 B4DR00 C0JYY8 B4DJZ8 B4DTQ3 H0YLU8 Q59FQ1 Q9UDH7
Accessions	AAA56833 AAB02658 AAD14091 AAF24515 AAP72971 AAR98971 ABD37052 ACN81317 ADM85889 ADM85894 ADO15978 AKA87353 AKA87354 CAJ33700 EAW84168 EAW84169 EAW84170 EAW84171 EAW84172 P01130 AA292214 AB209409 BAD92646 AK295612 BAG58495 AK296312 BAG59010 AK299038 BAG61112 AK300313 BAG62065 AY114155 AAM56036 BC014514 AAH14514 BM785950 BT007361 AAP36025 BX648281 DA008286 DB081391 DC306821 DQ893879 ABM84805 HM369522 M28219 AAA59509 S40543 AAB22609 S70123 AAB30338 XM_011528010 XP_011526312 XM_011528011 XP_011526313 XR_244074 NM_000527 NP_000518 NM_001195798 NP_001182727 NM_001195799 NP_001182728 NM_001195800 NP_001182729 NM_001195803 NP_001182732 NM_001195802
Function	Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein. Golgi apparatus. Early endosome. Late endosome. Cell surface. Lysosome. Note=Found distributed from the plasma membrane to intracellular compartments. Localizes to the Golgi apparatus, early and late endosomes/lysosomes and cell surface in the presence of PCSK9.
Top Pathways	Endocytosis, Toxoplasmosis, Hepatitis C, Bile secretion, Ovarian steroidogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LDLR / LDL Receptor ELISA Kit (Sandwich ELISA) - LS-F4388 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.124 ng/ml Range 8.192-800 pg/ml

Human LDLR / LDL Receptor ELISA Kit (Sandwich ELISA) - LS-F137 from LifeSpan Bioscience Category ELISA Kit Prices $600.00, $1,100.00, $2,520.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 8.192 pg/ml Range 8.192-800 pg/ml

Mouse LDLR / LDL Receptor ELISA Kit (Sandwich ELISA) - LS-F8668 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.058 ng/ml Range 8.192-800 pg/ml

Rat LDLR / LDL Receptor ELISA Kit (Sandwich ELISA) - LS-F11934 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 1.56 Range 8.192-800 pg/ml

Human LDLR / Low-density Lipoprotein Receptor ELISA Kit - RAB0707 from Sigma-Aldrich Category ELISA Kit Prices $633.00 Sizes 1 kt

Mouse LDL R Quantikine ELISA Kit - MLDLR0 from R&D Systems Category ELISA Kit Prices $479.00 Sizes 1 kit Sensitivity 0.064 ng/mL Range 0.3 - 20 ng/mL (Cell Culture Supernates, Tissue Homogenates, Serum, EDTA Plasma, Heparin Plasma)

Human LDL R DuoSet ELISA - DY2148 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 125.00 - 8,000 pg/mL

Mouse LDL R DuoSet ELISA - DY2255 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 62.50 - 4,000 pg/mL

Human LDL R Quantikine ELISA Kit - DLDLR0 from R&D Systems Category ELISA Kit Prices $519.00 Sizes 1 kit Sensitivity 10.3 pg/mL Range 62.5 - 4,000 pg/mL (Cell Culture Supernates, Cell Lysates, Serum, Heparin Plasma, Urine)

Human LDL Receptor ELISA kit - orb232162 from Biorbyt Category ELISA Kit Prices $604.00 Sizes 1 kit

Human LDLR ELISA Kit - abx152184 from Abbexa Category ELISA Kit Sensitivity 0.131 ng/ml Range 0.313 ng/ml - 20 ng/ml

Low Density Lipoprotein Receptor, LDLR, Human, ELISA Kit - E-EL-H1211 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Low density lipoprotein receptor, Human, ELISA Kit - E01L0218 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 1.0-25ng/mL,

Low-density lipoprotein receptor, LDLR, Human, ELISA Kit - E1008h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

Low Density Lipoprotein Receptor, LDLR, Rabbit, ELISA Kit - E-EL-RB2226 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

LDLR (Low Density Lipoprotein Receptor), Chicken, ELISA Kit - E-EL-Ch1893 from ARP American Research Products Category ELISA Kit Prices $773.00 Sizes 96 t

Low Density Lipoprotein Receptor, LDLR, Porcine, ELISA Kit - E-EL-P1711 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Low Density Lipoprotein Receptor, LDLR, Sheep, ELISA Kit - E-EL-S0776 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Low Density Lipoprotein Receptor, LDLR, Monkey, ELISA Kit - E-EL-MK1806 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Human LDL R ELISA - ELH-LDLR from RayBiotech Category ELISA Kit Prices $390.00, $702.00, $1,561.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 8 pg/ml Range 8 pg/ml - 2,000 pg/ml

Human LDLR ELISA Kit - HL0225 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine LDLR ELISA Kit - AL0225 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

LDLR, ELISA Kit - MBS2516228 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

LDLR, ELISA Kit - MBS2509079 from MyBioSource Category ELISA Kit Prices $490.00, $585.00, $2,475.00, $4,360.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

LDLR, ELISA Kit - MBS2502220 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

Search more