Gene Symbol | LDLR |
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Entrez Gene | 3949 |
Alt Symbol | FH, FHC, LDLCQ2 |
Species | Human |
Gene Type | protein-coding |
Description | low density lipoprotein receptor |
Other Description | LDL receptor|low-density lipoprotein receptor|low-density lipoprotein receptor class A domain-containing protein 3 |
Swissprots | H0YNT7 P01130 B4DII3 Q53ZD9 B4DR00 C0JYY8 B4DJZ8 B4DTQ3 H0YLU8 Q59FQ1 Q9UDH7 |
Accessions | AAA56833 AAB02658 AAD14091 AAF24515 AAP72971 AAR98971 ABD37052 ACN81317 ADM85889 ADM85894 ADO15978 AKA87353 AKA87354 CAJ33700 EAW84168 EAW84169 EAW84170 EAW84171 EAW84172 P01130 AA292214 AB209409 BAD92646 AK295612 BAG58495 AK296312 BAG59010 AK299038 BAG61112 AK300313 BAG62065 AY114155 AAM56036 BC014514 AAH14514 BM785950 BT007361 AAP36025 BX648281 DA008286 DB081391 DC306821 DQ893879 ABM84805 HM369522 M28219 AAA59509 S40543 AAB22609 S70123 AAB30338 XM_011528010 XP_011526312 XM_011528011 XP_011526313 XR_244074 NM_000527 NP_000518 NM_001195798 NP_001182727 NM_001195799 NP_001182728 NM_001195800 NP_001182729 NM_001195803 NP_001182732 NM_001195802 |
Function | Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein. Golgi apparatus. Early endosome. Late endosome. Cell surface. Lysosome. Note=Found distributed from the plasma membrane to intracellular compartments. Localizes to the Golgi apparatus, early and late endosomes/lysosomes and cell surface in the presence of PCSK9. |
Top Pathways | Endocytosis, Toxoplasmosis, Hepatitis C, Bile secretion, Ovarian steroidogenesis |
LDLR (B-10) - sc-373831 from Santa Cruz Biotechnology
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LDLR (N-17) - sc-11822 from Santa Cruz Biotechnology
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LDLR (F-7) - sc-373830 from Santa Cruz Biotechnology
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LDLR (C7) - sc-18823 from Santa Cruz Biotechnology
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LDLR (D-17) - sc-11823 from Santa Cruz Biotechnology
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LDLR (C-20) - sc-11824 from Santa Cruz Biotechnology
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LDLR (H-120) - sc-20744 from Santa Cruz Biotechnology
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Anti-LDL Receptor antibody - ab14056 from Abcam
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Anti-LDL Receptor antibody - ab175883 from Abcam
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Anti-LDL Receptor antibody - ab189170 from Abcam
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Anti-LDL Receptor antibody - ab134998 from Abcam
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Anti-LDL Receptor antibody - ab155578 from Abcam
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Anti-LDL Receptor antibody - ab30532 from Abcam
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Anti-LDL Receptor antibody (Biotin) - ab50296 from Abcam
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Anti-LDL Receptor antibody [EP1553Y] - ab52818 from Abcam
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Anti-LDL Receptor antibody [EP1553Y] (Alexa Fluor® 488) - ab196377 from Abcam
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Anti-LDL Receptor antibody [EP1553Y] (Alexa Fluor® 647) - ab196160 from Abcam
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Anti-LDL Receptor antibody [EP1553Y] (HRP) - ab195516 from Abcam
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Anti-LDL Receptor antibody [mAbcam60107] - ab60107 from Abcam
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Anti-LDL Receptor antibody [MM0609-11A2] - ab135196 from Abcam
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Anti-LDLR / LDL Receptor Antibody (aa184-195, Biotin) - LS-C8503 from LifeSpan Bioscience
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Anti-LDLR / LDL Receptor Antibody (Biotin) - LS-C8505 from LifeSpan Bioscience
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Anti-LDLR / LDL Receptor Antibody (aa184-196) - LS-C8502 from LifeSpan Bioscience
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Anti-LDLR / LDL Receptor Antibody - LS-C8504 from LifeSpan Bioscience
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Anti-LDLR / LDL Receptor Antibody (Extracellular Domain, Biotin) - LS-C8509 from LifeSpan Bioscience
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