LDLR

Gene Symbol LDLR
Entrez Gene 3949
Alt Symbol FH, FHC, LDLCQ2
Species Human
Gene Type protein-coding
Description low density lipoprotein receptor
Other Description LDL receptor|low-density lipoprotein receptor|low-density lipoprotein receptor class A domain-containing protein 3
Swissprots H0YNT7 P01130 B4DII3 Q53ZD9 B4DR00 C0JYY8 B4DJZ8 B4DTQ3 H0YLU8 Q59FQ1 Q9UDH7
Accessions AAA56833 AAB02658 AAD14091 AAF24515 AAP72971 AAR98971 ABD37052 ACN81317 ADM85889 ADM85894 ADO15978 AKA87353 AKA87354 CAJ33700 EAW84168 EAW84169 EAW84170 EAW84171 EAW84172 P01130 AA292214 AB209409 BAD92646 AK295612 BAG58495 AK296312 BAG59010 AK299038 BAG61112 AK300313 BAG62065 AY114155 AAM56036 BC014514 AAH14514 BM785950 BT007361 AAP36025 BX648281 DA008286 DB081391 DC306821 DQ893879 ABM84805 HM369522 M28219 AAA59509 S40543 AAB22609 S70123 AAB30338 XM_011528010 XP_011526312 XM_011528011 XP_011526313 XR_244074 NM_000527 NP_000518 NM_001195798 NP_001182727 NM_001195799 NP_001182728 NM_001195800 NP_001182729 NM_001195803 NP_001182732 NM_001195802
Function Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
Subcellular Location Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein. Golgi apparatus. Early endosome. Late endosome. Cell surface. Lysosome. Note=Found distributed from the plasma membrane to intracellular compartments. Localizes to the Golgi apparatus, early and late endosomes/lysosomes and cell surface in the presence of PCSK9.
Top Pathways Endocytosis, Toxoplasmosis, Hepatitis C, Bile secretion, Ovarian steroidogenesis

LDLR (B-10) - sc-373831 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LDLR (B-10): sc-373831. Western blot analysis of human recombinant LDLR fusion protein.

LDLR (N-17) - sc-11822 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LDLR (N-17): sc-11822. Immunoperoxidase staining of formalin fixed, paraffin-embedded human upper stomach tissue showing cytoplasmic staining of glandular cells.

LDLR (F-7) - sc-373830 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LDLR (F-7): sc-373830. Western blot analysis of human recombinant LDLR fusion protein (A) and LDLR expression in Raji whole cell lysate (B).

LDLR (C7) - sc-18823 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LDLR (C7): sc-18823. Western blot analysis of LDLR expression in bovine adrenal tissue extract. Kindly provided by Dr. Joseph L. Goldstein, University of Texas Southwestern Medical Center.

LDLR (D-17) - sc-11823 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

LDLR (C-20) - sc-11824 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LDLR (C-20): sc-11824. Western blot analysis of purified human LDLR.

LDLR (H-120) - sc-20744 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
LDLR (H-120): sc-20744. Western blot analysis of LDLR expression in CCD-1064Sk whole cell lysate.

Anti-LDL Receptor antibody - ab14056 from Abcam

Prices $384.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal
Transiently transfected 293 cells probed with ab14056.

Anti-LDL Receptor antibody - ab175883 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-LDL Receptor antibody (ab175883) at 1/1000 dilution + Mouse lung tissue lysate at 35 µgdeveloped using the ECL technique

Anti-LDL Receptor antibody - ab189170 from Abcam

Prices $378.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of Formalin fixed, paraffin-embedded Human liver tissue labelling LDL Receptor with ab189170 at 10µg/ml. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Anti-LDL Receptor antibody - ab134998 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC image of LDL Receptor staining in human lung formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab134998, 1/1000 dilution, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times. 

Anti-LDL Receptor antibody - ab155578 from Abcam

Prices $370.00
Sizes 250 µg
Host Rabbit
Clonality Polyclonal

Anti-LDL Receptor antibody - ab30532 from Abcam

Prices $391.00
Sizes 75 µg
Host Rabbit
Clonality Polyclonal

Anti-LDL Receptor antibody (Biotin) - ab50296 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-LDL Receptor antibody [EP1553Y] - ab52818 from Abcam

Host Rabbit
Clonality Monoclonal
Clone EP1553Y
ab52818 at 1/100 dilution staining LDL receptor in HepG2 cells by Immunocytochemistry.

Anti-LDL Receptor antibody [EP1553Y] (Alexa Fluor® 488) - ab196377 from Abcam

Host Rabbit
Clonality Monoclonal
Clone EP1553Y
Overlay histogram showing HeLa cells stained with ab196377 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab196377, 1/500 dilution) for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) Alexa Fluor® 488 used at the same concentration and conditions as the primary antibody. Unlabelled sample (blue line) was also used as a control.Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.This antibody gave a positive signal in HeLa fixed with 4% formaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-LDL Receptor antibody [EP1553Y] (Alexa Fluor® 647) - ab196160 from Abcam

Host Rabbit
Clonality Monoclonal
Clone EP1553Y
Overlay histogram showing HeLa cells stained with ab196160 (red line). The cells were fixed with 4% formaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab196160, 1/50 dilution) for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) Alexa Fluor® 647 (ab199093) used at the same concentration and conditions as the primary antibody. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a solid-state 25mW red diode laser (635 nm) and 675/30 bandpass filter. This antibody gave a positive signal in HeLa cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-LDL Receptor antibody [EP1553Y] (HRP) - ab195516 from Abcam

Host Rabbit
Clonality Monoclonal
Clone EP1553Y
IHC image of LDL Receptor staining in a section of formalin-fixed paraffin-embedded normal human adrenal gland, performed on a Leica BOND. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20mins. The section was then incubated with ab195516 at 1/100 dilution, for 15 mins at room temperature. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. The inset negative control image is taken from an identical assay without primary antibody.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-LDL Receptor antibody [mAbcam60107] - ab60107 from Abcam

Host Mouse
Clonality Monoclonal
Clone mAbcam60107
ICC/IF image of ab60107 stained HeLa cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab60107, 10µg/ml) overnight at +4°C. The secondary antibody (green) was ab96879, DyLight® 488 goat anti-mouse IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM. This antibody also gave a positive result in 100% methanol fixed (5 min) Hek293, HepG2 and MCF7 cells at 10µg/ml.

Anti-LDL Receptor antibody [MM0609-11A2] - ab135196 from Abcam

Host Mouse
Clonality Monoclonal
Clone MM0609-11A2

Anti-LDLR / LDL Receptor Antibody (aa184-195, Biotin) - LS-C8503 from LifeSpan Bioscience

Prices $465.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-LDLR / LDL Receptor Antibody (Biotin) - LS-C8505 from LifeSpan Bioscience

Prices $495.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal

Anti-LDLR / LDL Receptor Antibody (aa184-196) - LS-C8502 from LifeSpan Bioscience

Prices $325.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-LDLR / LDL Receptor Antibody - LS-C8504 from LifeSpan Bioscience

Prices $590.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-LDLR / LDL Receptor Antibody (Extracellular Domain, Biotin) - LS-C8509 from LifeSpan Bioscience

Prices $755.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal
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