LDLR

Gene Symbol	LDLR
Entrez Gene	3949
Alt Symbol	FH, FHC, LDLCQ2
Species	Human
Gene Type	protein-coding
Description	low density lipoprotein receptor
Other Description	LDL receptor|low-density lipoprotein receptor|low-density lipoprotein receptor class A domain-containing protein 3
Swissprots	H0YNT7 P01130 B4DII3 Q53ZD9 B4DR00 C0JYY8 B4DJZ8 B4DTQ3 H0YLU8 Q59FQ1 Q9UDH7
Accessions	AAA56833 AAB02658 AAD14091 AAF24515 AAP72971 AAR98971 ABD37052 ACN81317 ADM85889 ADM85894 ADO15978 AKA87353 AKA87354 CAJ33700 EAW84168 EAW84169 EAW84170 EAW84171 EAW84172 P01130 AA292214 AB209409 BAD92646 AK295612 BAG58495 AK296312 BAG59010 AK299038 BAG61112 AK300313 BAG62065 AY114155 AAM56036 BC014514 AAH14514 BM785950 BT007361 AAP36025 BX648281 DA008286 DB081391 DC306821 DQ893879 ABM84805 HM369522 M28219 AAA59509 S40543 AAB22609 S70123 AAB30338 XM_011528010 XP_011526312 XM_011528011 XP_011526313 XR_244074 NM_000527 NP_000518 NM_001195798 NP_001182727 NM_001195799 NP_001182728 NM_001195800 NP_001182729 NM_001195803 NP_001182732 NM_001195802
Function	Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein. Golgi apparatus. Early endosome. Late endosome. Cell surface. Lysosome. Note=Found distributed from the plasma membrane to intracellular compartments. Localizes to the Golgi apparatus, early and late endosomes/lysosomes and cell surface in the presence of PCSK9.
Top Pathways	Endocytosis, Toxoplasmosis, Hepatitis C, Bile secretion, Ovarian steroidogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human LDL Receptor protein fragment - ab198760 from Abcam Category Protein Prices $1,281.00 Sizes 50 µg Source HEK 293 cells Species Human

Human LDL Receptor full length protein - ab152498 from Abcam Category Protein Source Wheat germ Species Human

Human LDL Receptor protein fragment - ab112317 from Abcam Category Protein Source Wheat germ Species Human

Human LDL Receptor protein fragment - ab153782 from Abcam Category Protein Source HEK 293 cells Species Human

LDLR / LDL Receptor Antibody Blocking Peptide - LS-E9875 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LDLR / LDL Receptor Antibody Blocking Peptide - LS-E30701 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

LDL R Blocking Peptide - NBP1-06709PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 100 µl Species Human

LDL R Partial Recombinant Protein - H00003949-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

LDL R Recombinant Protein - H00003949-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

LDL R Blocking Peptide - NBP1-77029PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

LDLR-Antibody-Center-Blocking-Peptide - BP8960c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human LDL R - 2148-LD-025 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ala22-Arg788, with a C-terminal 6-His tag

Recombinant Human LDL R, CF - 2148-LD-025/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ala22-Arg788, with a C-terminal 6-His tag

Recombinant Human LDL R (High Purity), CF - 2148-HP-025 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ala22-Arg788, with a C-terminal 6-His tag

Human LDLR protein - orb163428 from Biorbyt Category Protein Prices $323.00, $476.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human LDLR His tag protein - orb83196 from Biorbyt Category Protein Prices $357.00, $612.00 Sizes 20 μg, 50 μg Source Human Species Human

LDLR Blocking Peptide - 33R-10949 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

LDLR - H00003949-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

LDLR - H00003949-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Source in vitro transl. Species Human

LDLR - H00003949-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Source in vitro transl. Species Human

LDLR - H00003949-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

LDLR - H00003949-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

LDLR Control Peptide - AP30494CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Low-Density Lipoprotein Receptor, LDLR, Human, Recombinant - 19-CA88 from ARP American Research Products Category Protein Prices $119.00 Sizes 10 µg Source HEK293 Species Human

LDL-R Peptide - 5163P from ProSci Category Peptide Species Human

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