LDLR

Gene Symbol LDLR
Entrez Gene 3949
Alt Symbol FH, FHC, LDLCQ2
Species Human
Gene Type protein-coding
Description low density lipoprotein receptor
Other Description LDL receptor|low-density lipoprotein receptor|low-density lipoprotein receptor class A domain-containing protein 3
Swissprots H0YNT7 P01130 B4DII3 Q53ZD9 B4DR00 C0JYY8 B4DJZ8 B4DTQ3 H0YLU8 Q59FQ1 Q9UDH7
Accessions AAA56833 AAB02658 AAD14091 AAF24515 AAP72971 AAR98971 ABD37052 ACN81317 ADM85889 ADM85894 ADO15978 AKA87353 AKA87354 CAJ33700 EAW84168 EAW84169 EAW84170 EAW84171 EAW84172 P01130 AA292214 AB209409 BAD92646 AK295612 BAG58495 AK296312 BAG59010 AK299038 BAG61112 AK300313 BAG62065 AY114155 AAM56036 BC014514 AAH14514 BM785950 BT007361 AAP36025 BX648281 DA008286 DB081391 DC306821 DQ893879 ABM84805 HM369522 M28219 AAA59509 S40543 AAB22609 S70123 AAB30338 XM_011528010 XP_011526312 XM_011528011 XP_011526313 XR_244074 NM_000527 NP_000518 NM_001195798 NP_001182727 NM_001195799 NP_001182728 NM_001195800 NP_001182729 NM_001195803 NP_001182732 NM_001195802
Function Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
Subcellular Location Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein. Golgi apparatus. Early endosome. Late endosome. Cell surface. Lysosome. Note=Found distributed from the plasma membrane to intracellular compartments. Localizes to the Golgi apparatus, early and late endosomes/lysosomes and cell surface in the presence of PCSK9.
Top Pathways Endocytosis, Toxoplasmosis, Hepatitis C, Bile secretion, Ovarian steroidogenesis

LDLR CRISPR/Cas9 KO Plasmid (h) - sc-400645 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LDLR HDR Plasmid (h) - sc-400645-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LDLR Double Nickase Plasmid (h) - sc-400645-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LDLR Double Nickase Plasmid (h2) - sc-400645-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LDLR CRISPR Activation Plasmid (h) - sc-400645-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LDLR CRISPR Activation Plasmid (h2) - sc-400645-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LDLR Lentiviral Activation Particles (h) - sc-400645-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LDLR Lentiviral Activation Particles (h2) - sc-400645-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LDLR siRNA (h) - sc-35802 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LDLR shRNA Plasmid (h) - sc-35802-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LDLR shRNA (h) Lentiviral Particles - sc-35802-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LDL R RNAi - H00003949-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU152551 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11625 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11625 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11487 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11487

LDLR siRNA (Human) - CRH2673 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human LDLR (NM_000527.4) - SHH329335 from Creative biogene

Category siRNA
Species Reactivities Human

LDLR shRNA Plasmid (Human) - CHH2673 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LDLR miRNA 3'UTR clone - MiUTR3H-08845 from Creative biogene

Species Reactivities Human
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