FLNB

Gene Symbol	FLNB
Entrez Gene	2317
Alt Symbol	ABP-278, ABP-280, AOI, FH1, FLN-B, FLN1L, LRS1, SCT, TABP, TAP
Species	Human
Gene Type	protein-coding
Description	filamin B, beta
Other Description	ABP-280 homolog|Larsen syndrome 1 (autosomal dominant)|actin binding protein 278|actin-binding-like protein|beta-filamin|filamin homolog 1|filamin-3|filamin-B|thyroid autoantigen
Swissprots	Q59EC2 B2ZZ83 Q8WXT0 Q9NT26 Q8WXS9 C9JMC4 Q60FE7 B2ZZ85 C9JKE6 B2ZZ84 Q8WXT2 Q9UEV9 Q6MZJ1 O75369 Q9NRB5 Q13706 Q8WXT1 Q8WXT3
Accessions	AAF72339 AAL68440 AAL68441 AAL68442 AAL68443 EAW65352 EAW65353 EAW65354 EAW65355 EAW65356 EAW65357 O75369 AB191258 BAD52434 AB209889 BAD93126 AB371580 BAG48309 AB371581 BAG48310 AB371582 BAG48311 AF042166 AAC39842 AF043045 AAC33845 AF238609 AAF97046 AF353666 AAL68439 AK022486 AL137574 CAB70818 AL699183 AL833551 BC156184 AAI56185 BX641085 CAE46040 CR749793 CAH18654 M62994 AAA35505 XM_005264977 XP_005265034 XM_005264978 XP_005265035 XM_005264981 XP_005265038 XR_940396 NM_001164317 NP_001157789 NM_001164318 NP_001157790 NM_001164319 NP_001157791 NM_001457 NP_001448
Function	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
Subcellular Location	Isoform 3: Cytoplasm, cytoskeleton. Note=Predominantly localized at actin stress fibers.
Tissue Specificity	Ubiquitous. Isoform 1 and isoform 2 are expressed in placenta, bone marrow, brain, umbilical vein endothelial cells (HUVEC), retina and skeletal muscle. Isoform 1 is predominantly expressed in prostate, uterus, liver, thyroid, stomach, lymph node, small intestine, spleen, skeletal muscle, kidney, placenta, pancreas, heart, lung, platelets, endothelial cells, megakaryocytic and erythroleukemic cell lines. Isoform 2 is predominantly expressed in spinal cord, platelet and Daudi cells. Also expressed in thyroid adenoma, neurofibrillary tangles (NFT), senile plaques in the hippocampus and cerebral cortex in Alzheimer disease (AD). Isoform 3 and isoform 6 are expressed predominantly in lung, heart, skeletal muscle, testis, spleen, thymus and leukocytes. Isoform 4 and isoform 5 are expressed in heart. {ECO:0000269|PubMed:11807098, ECO:0000269|PubMed:8327473, ECO:0000269|PubMed:9651345, ECO:0000269|PubMed:9694715}.
Top Pathways	Focal adhesion, MAPK signaling pathway, Salmonella infection, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FLNB / TAP ELISA Kit (Sandwich ELISA) - LS-F6476 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 5.4 pg/ml Range 15.63-1000 pg/ml

Mouse FLNB / TAP ELISA Kit (Sandwich ELISA) - LS-F10663 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 15.63-1000 pg/ml

Filamin B Beta (FLNb), Human, ELISA Kit - SEE931Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 5.4pg/mL Range 15.6-1,000pg/mL

Filamin B, Beta, Human, ELISA Kit - E01F0100 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 1.0-25ng/mL,

Filamin B, Beta, FLNb, Human, ELISA Kit - E-EL-H2096 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Filamin B, Beta, FLNb, Rabbit, ELISA Kit - E-EL-RB1738 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Filamin B, Beta, FLNb, Chicken, ELISA Kit - E-EL-Ch0017 from ARP American Research Products Category ELISA Kit Prices $445.50 Sizes 96 t

Filamin B, Beta, FLNb, Porcine, ELISA Kit - E-EL-P0181 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Filamin B, Beta, FLNb, Sheep, ELISA Kit - E-EL-S0094 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Filamin B, Beta, FLNb, Monkey, ELISA Kit - E-EL-MK0052 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human FLNB ELISA Kit - HF0107 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine FLNB ELISA Kit - AF0107 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Filamin B, Beta, ELISA Kit - MBS734984 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Filamin B, beta, ELISA Kit - MBS731914 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,850.00, $5,340.00 Sizes 48 -strip-wells- (Competitive), 96 -strip-wells- (Competitive), 5x96-strip-wells- (Competitive), 10x96-strip-wells- (Competitive) Sensitivity 0.1 ng/mL.

Filamin B, Beta, ELISA Kit - MBS725017 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Filamin B, Beta, ELISA Kit - MBS724065 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Filamin B, Beta, ELISA Kit - MBS743035 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Filamin B, Beta, ELISA Kit - MBS732358 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Filamin B, Beta, ELISA Kit - MBS740299 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Filamin B, Beta, ELISA Kit - MBS737756 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Filamin B, Beta, ELISA Kit - MBS743401 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Filamin B, Beta, ELISA Kit - MBS735469 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Filamin B Beta (FLNb), ELISA Kit - MBS2020639 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 5.4pg/mL. Range 15.63-1000pg/mL

Filamin B, Beta, ELISA Kit - MBS734212 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

ELISA Kit for Filamin B Beta (FLNb) - SEE931Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 5.4pg/mL. Range 15.63-1000pg/mL The standard curve concentrations used for the ELISA’s were 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL, 15.63pg/mL

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