FLNB

Gene Symbol	FLNB
Entrez Gene	2317
Alt Symbol	ABP-278, ABP-280, AOI, FH1, FLN-B, FLN1L, LRS1, SCT, TABP, TAP
Species	Human
Gene Type	protein-coding
Description	filamin B, beta
Other Description	ABP-280 homolog|Larsen syndrome 1 (autosomal dominant)|actin binding protein 278|actin-binding-like protein|beta-filamin|filamin homolog 1|filamin-3|filamin-B|thyroid autoantigen
Swissprots	Q59EC2 B2ZZ83 Q8WXT0 Q9NT26 Q8WXS9 C9JMC4 Q60FE7 B2ZZ85 C9JKE6 B2ZZ84 Q8WXT2 Q9UEV9 Q6MZJ1 O75369 Q9NRB5 Q13706 Q8WXT1 Q8WXT3
Accessions	AAF72339 AAL68440 AAL68441 AAL68442 AAL68443 EAW65352 EAW65353 EAW65354 EAW65355 EAW65356 EAW65357 O75369 AB191258 BAD52434 AB209889 BAD93126 AB371580 BAG48309 AB371581 BAG48310 AB371582 BAG48311 AF042166 AAC39842 AF043045 AAC33845 AF238609 AAF97046 AF353666 AAL68439 AK022486 AL137574 CAB70818 AL699183 AL833551 BC156184 AAI56185 BX641085 CAE46040 CR749793 CAH18654 M62994 AAA35505 XM_005264977 XP_005265034 XM_005264978 XP_005265035 XM_005264981 XP_005265038 XR_940396 NM_001164317 NP_001157789 NM_001164318 NP_001157790 NM_001164319 NP_001157791 NM_001457 NP_001448
Function	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
Subcellular Location	Isoform 3: Cytoplasm, cytoskeleton. Note=Predominantly localized at actin stress fibers.
Tissue Specificity	Ubiquitous. Isoform 1 and isoform 2 are expressed in placenta, bone marrow, brain, umbilical vein endothelial cells (HUVEC), retina and skeletal muscle. Isoform 1 is predominantly expressed in prostate, uterus, liver, thyroid, stomach, lymph node, small intestine, spleen, skeletal muscle, kidney, placenta, pancreas, heart, lung, platelets, endothelial cells, megakaryocytic and erythroleukemic cell lines. Isoform 2 is predominantly expressed in spinal cord, platelet and Daudi cells. Also expressed in thyroid adenoma, neurofibrillary tangles (NFT), senile plaques in the hippocampus and cerebral cortex in Alzheimer disease (AD). Isoform 3 and isoform 6 are expressed predominantly in lung, heart, skeletal muscle, testis, spleen, thymus and leukocytes. Isoform 4 and isoform 5 are expressed in heart. {ECO:0000269|PubMed:11807098, ECO:0000269|PubMed:8327473, ECO:0000269|PubMed:9651345, ECO:0000269|PubMed:9694715}.
Top Pathways	Focal adhesion, MAPK signaling pathway, Salmonella infection, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Filamin B protein fragment - ab158452 from Abcam Category Protein Source Wheat germ Species Human

FLNB / TAP Antibody Blocking Peptide - LS-E26206 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Filamin B Protein - H00002317-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Filamin B blocking peptide - GTX89235-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Filamin - Filamin Protein (OPPA01412) - OPPA01412 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source Chicken Gizzard

Human Filamin B Beta Protein - abx066661 from Abbexa Category Protein Source E.coli Species Human

FLNB Peptide - AC21-1037-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Filamin-B - H00002317-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Filamin-B - H00002317-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Filamin B Beta (FLNb), Human - 20-9036 from ARP American Research Products Category Protein Prices $495.00 Sizes 50 µg Source E.coli Species Human

FLNB Peptide - 45-597P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

Recombinant Filamin B Beta (FLNb) - RPE931Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Filamin B Beta (FLNb) - RPE931Hu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Filamin B Beta (FLNb) - RPE931Hu03 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Filamin B Beta (FLNb) - RPE931Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Filamin B Beta (FLNb) - RPE931Hu02 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Filamin B Beta (FLNb) - RPE931Hu03 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Filamin-B(FLNB) ,partial - CSB-YP008725HU CSB-EP008725HU CSB-BP008725HU CSB-MP008725HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

FLNB, Peptide - MBS425481 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Bovine

Filamin B Recombinant Protein Antigen - NBP1-90286PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Filamin B Recombinant Protein Antigen - NBP1-90285PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

FLNB-Blocking-Peptide-N-Term - BP21864a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FLNB-Blocking-Peptide-N-Term - BP21863a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FLNB Peptide, Human - M34GP05780H from Creative Peptides Category Peptide Source Synthetic. Species Human

Filamin B Beta, Recombinant Protein - MBS2031549 from MyBioSource Category Protein Prices $185.00, $385.00, $590.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Search more