FLNB

Gene Symbol FLNB
Entrez Gene 2317
Alt Symbol ABP-278, ABP-280, AOI, FH1, FLN-B, FLN1L, LRS1, SCT, TABP, TAP
Species Human
Gene Type protein-coding
Description filamin B, beta
Other Description ABP-280 homolog|Larsen syndrome 1 (autosomal dominant)|actin binding protein 278|actin-binding-like protein|beta-filamin|filamin homolog 1|filamin-3|filamin-B|thyroid autoantigen
Swissprots Q59EC2 B2ZZ83 Q8WXT0 Q9NT26 Q8WXS9 C9JMC4 Q60FE7 B2ZZ85 C9JKE6 B2ZZ84 Q8WXT2 Q9UEV9 Q6MZJ1 O75369 Q9NRB5 Q13706 Q8WXT1 Q8WXT3
Accessions AAF72339 AAL68440 AAL68441 AAL68442 AAL68443 EAW65352 EAW65353 EAW65354 EAW65355 EAW65356 EAW65357 O75369 AB191258 BAD52434 AB209889 BAD93126 AB371580 BAG48309 AB371581 BAG48310 AB371582 BAG48311 AF042166 AAC39842 AF043045 AAC33845 AF238609 AAF97046 AF353666 AAL68439 AK022486 AL137574 CAB70818 AL699183 AL833551 BC156184 AAI56185 BX641085 CAE46040 CR749793 CAH18654 M62994 AAA35505 XM_005264977 XP_005265034 XM_005264978 XP_005265035 XM_005264981 XP_005265038 XR_940396 NM_001164317 NP_001157789 NM_001164318 NP_001157790 NM_001164319 NP_001157791 NM_001457 NP_001448
Function Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
Subcellular Location Isoform 3: Cytoplasm, cytoskeleton. Note=Predominantly localized at actin stress fibers.
Tissue Specificity Ubiquitous. Isoform 1 and isoform 2 are expressed in placenta, bone marrow, brain, umbilical vein endothelial cells (HUVEC), retina and skeletal muscle. Isoform 1 is predominantly expressed in prostate, uterus, liver, thyroid, stomach, lymph node, small intestine, spleen, skeletal muscle, kidney, placenta, pancreas, heart, lung, platelets, endothelial cells, megakaryocytic and erythroleukemic cell lines. Isoform 2 is predominantly expressed in spinal cord, platelet and Daudi cells. Also expressed in thyroid adenoma, neurofibrillary tangles (NFT), senile plaques in the hippocampus and cerebral cortex in Alzheimer disease (AD). Isoform 3 and isoform 6 are expressed predominantly in lung, heart, skeletal muscle, testis, spleen, thymus and leukocytes. Isoform 4 and isoform 5 are expressed in heart. {ECO:0000269|PubMed:11807098, ECO:0000269|PubMed:8327473, ECO:0000269|PubMed:9651345, ECO:0000269|PubMed:9694715}.
Top Pathways Focal adhesion, MAPK signaling pathway, Salmonella infection, Proteoglycans in cancer

Filamin B (D7E4W) Rabbit mAb - 12979 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7E4W
Western blot analysis of extracts from various cell types using Filamin B (D7E4W) Rabbit mAb.

Filamin B Antibody - 8949 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using Filamin B Antibody.

Filamin 3 (A-4) - sc-271698 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Filamin 3 (A-4): sc-271698. Western blot analysis of Filamin 3 expression in U-87 MG (A) and Jurkat (B) whole cell lysates.

Filamin 3 (D-10) - sc-271561 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Filamin 3 (D-10): sc-271561. Western blot analysis of Filamin 3 expression in Jurkat whole cell lysate.

Filamin 3 (C-17) - sc-48500 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Filamin 3 (C-17): sc-48500. Western blot analysis of Filamin 3 expression in HeLa (A), NIH/3T3 (B), C6 (C) and U-87 MG (D) whole cell lysates and mouse postnatal brain (E) and mouse embryo (F) tissue extracts. Note presence of proteolytic cleavage products.

Filamin 3 (C-13) - sc-48499 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Filamin 3 (B-7) - sc-166671 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Filamin 3 (B-7): sc-166671. Western blot analysis of Filamin 3 expression in NIH/3T3 whole cell lysate.

Filamin 3 (F-8) - sc-376241 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Filamin 3 (F-8): sc-376241. Western blot analysis of Filamin 3 expression in Jurkat whole cell lysate.

Filamin 3 (D-6) - sc-166484 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Filamin 3 (D-6): sc-166484. Western blot analysis of Filamin 3 expression in HeLa (A), Jurkat (B), K-562 (C), U-87 MG (D), NIH/3T3 (E), C6 (F) and KNRK (G) whole cell lysates.

Filamin 3 (H-65) - sc-134571 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Filamin 3 (H-65): sc-134571. Western blot analysis of Filamin 3 expression in U-87 MG (A) and NIH/3T3 (B) whole cell lysates.

Filamin 3 (N-15) - sc-48501 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Filamin 3 (N-15): sc-48501. Western blot analysis of Filamin 3 expression in HeLa (A), NIH/3T3 (B), C6 (C) and U-87 MG (D) whole cell lysates and mouse postnatal brain (E) and mouse embryo (F) tissue extracts. Note presence of proteolytic cleavage products.

Filamin 3 (N-16) - sc-48502 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Filamin 3 (N-16): sc-48502. Western blot analysis of Filamin 3 expression in HeLa (A), NIH/3T3 (B), C6 (C) and U-87 MG (D) whole cell lysates and mouse postnatal brain (E) and mouse embryo (F) tissue extracts. Note presence of proteolytic cleavage products.

Anti-FLNB antibody - ab97457 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-FLNB antibody (ab97457) at 1/1000 dilution + A431 whole cell lysate at 30 µg

Anti-FLNB antibody - ab84905 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab84905, at a 1/500 dilution, staining FLNB in formalin fixed, paraffin embedded human prostate carcinoma tissue by Immunohistochemistry. Detection: red fluorescent, highly cross absorbed goat anti-rabbit IgG antibody used at a dilution of 1/100.

Anti-FLNB / TAP Antibody (aa1938-1950) - LS-C54845 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-FLNB / TAP Antibody (aa1225-1275) - LS-C125612 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FLNB / TAP Antibody (aa1175-1457, Biotin) - LS-C298043 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FLNB / TAP Antibody (aa1175-1457, Biotin) - LS-C299999 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FLNB / TAP Antibody (FITC) - LS-C301817 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FLNB / TAP Antibody (aa1225-1275) - LS-C288511 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Filamin B by Western Blot. Samples: Whole cell lysate from HeLa (5, 15 and 50 ug) and 293T (T; 50 ug) cells. Antibodies: Affinity purified rabbit anti-Filamin B antibody used for WB at 0.04 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-FLNB / TAP Antibody (aa1175-1457, FITC) - LS-C304171 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FLNB / TAP Antibody (aa1175-1457) - LS-C293947 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant FLNB / TAP.

Anti-FLNB / TAP Antibody (aa975-1025) - LS-C288510 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Filamin B by Western Blot. Samples: Whole cell lysate from HeLa (5, 15 and 50 ug) and 293T (T; 50 ug) cells. Antibodies: Affinity purified rabbit anti-Filamin B antibody used for WB at 0.04 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-FLNB / TAP Antibody (aa2552-2602) - LS-C288512 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Filamin B by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-Filamin B used at a dilution of 1:200 (1 Detection: DAB.

Anti-FLNB / TAP Antibody - LS-C335245 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of HeLa cell line, using FLNB antibody.
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