| Gene Symbol | FLNB |
|---|---|
| Entrez Gene | 2317 |
| Alt Symbol | ABP-278, ABP-280, AOI, FH1, FLN-B, FLN1L, LRS1, SCT, TABP, TAP |
| Species | Human |
| Gene Type | protein-coding |
| Description | filamin B, beta |
| Other Description | ABP-280 homolog|Larsen syndrome 1 (autosomal dominant)|actin binding protein 278|actin-binding-like protein|beta-filamin|filamin homolog 1|filamin-3|filamin-B|thyroid autoantigen |
| Swissprots | Q59EC2 B2ZZ83 Q8WXT0 Q9NT26 Q8WXS9 C9JMC4 Q60FE7 B2ZZ85 C9JKE6 B2ZZ84 Q8WXT2 Q9UEV9 Q6MZJ1 O75369 Q9NRB5 Q13706 Q8WXT1 Q8WXT3 |
| Accessions | AAF72339 AAL68440 AAL68441 AAL68442 AAL68443 EAW65352 EAW65353 EAW65354 EAW65355 EAW65356 EAW65357 O75369 AB191258 BAD52434 AB209889 BAD93126 AB371580 BAG48309 AB371581 BAG48310 AB371582 BAG48311 AF042166 AAC39842 AF043045 AAC33845 AF238609 AAF97046 AF353666 AAL68439 AK022486 AL137574 CAB70818 AL699183 AL833551 BC156184 AAI56185 BX641085 CAE46040 CR749793 CAH18654 M62994 AAA35505 XM_005264977 XP_005265034 XM_005264978 XP_005265035 XM_005264981 XP_005265038 XR_940396 NM_001164317 NP_001157789 NM_001164318 NP_001157790 NM_001164319 NP_001157791 NM_001457 NP_001448 |
| Function | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| Subcellular Location | Isoform 3: Cytoplasm, cytoskeleton. Note=Predominantly localized at actin stress fibers. |
| Tissue Specificity | Ubiquitous. Isoform 1 and isoform 2 are expressed in placenta, bone marrow, brain, umbilical vein endothelial cells (HUVEC), retina and skeletal muscle. Isoform 1 is predominantly expressed in prostate, uterus, liver, thyroid, stomach, lymph node, small intestine, spleen, skeletal muscle, kidney, placenta, pancreas, heart, lung, platelets, endothelial cells, megakaryocytic and erythroleukemic cell lines. Isoform 2 is predominantly expressed in spinal cord, platelet and Daudi cells. Also expressed in thyroid adenoma, neurofibrillary tangles (NFT), senile plaques in the hippocampus and cerebral cortex in Alzheimer disease (AD). Isoform 3 and isoform 6 are expressed predominantly in lung, heart, skeletal muscle, testis, spleen, thymus and leukocytes. Isoform 4 and isoform 5 are expressed in heart. {ECO:0000269|PubMed:11807098, ECO:0000269|PubMed:8327473, ECO:0000269|PubMed:9651345, ECO:0000269|PubMed:9694715}. |
| Top Pathways | Focal adhesion, MAPK signaling pathway, Salmonella infection, Proteoglycans in cancer |
Filamin 3 CRISPR/Cas9 KO Plasmid (h) - sc-402897 from Santa Cruz Biotechnology
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Filamin 3 HDR Plasmid (h) - sc-402897-HDR from Santa Cruz Biotechnology
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Filamin 3 Double Nickase Plasmid (h) - sc-402897-NIC from Santa Cruz Biotechnology
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Filamin 3 Double Nickase Plasmid (h2) - sc-402897-NIC-2 from Santa Cruz Biotechnology
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Filamin 3 CRISPR Activation Plasmid (h) - sc-402897-ACT from Santa Cruz Biotechnology
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Filamin 3 CRISPR Activation Plasmid (h2) - sc-402897-ACT-2 from Santa Cruz Biotechnology
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Filamin 3 Lentiviral Activation Particles (h) - sc-402897-LAC from Santa Cruz Biotechnology
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Filamin 3 Lentiviral Activation Particles (h2) - sc-402897-LAC-2 from Santa Cruz Biotechnology
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Filamin 3 siRNA (h) - sc-60641 from Santa Cruz Biotechnology
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Filamin 3 shRNA Plasmid (h) - sc-60641-SH from Santa Cruz Biotechnology
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Filamin 3 shRNA (h) Lentiviral Particles - sc-60641-V from Santa Cruz Biotechnology
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Filamin B RNAi - H00002317-R01 from Novus Biologicals
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MISSION® esiRNA - EHU091691 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8823 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8823 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12679 from Sigma-Aldrich
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FLNB siRNA (Human) - CRH1622 from Cohesion Biosciences
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FLNB - MBS827089 from MyBioSource
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shRNA set against Human FLNB (NM_001457.3) - SHH295673 from Creative biogene
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Human FLNB siRNA - orb262124 from Biorbyt
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FLNB shRNA Plasmid (Human) - CHH1622 from Cohesion Biosciences
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FLNB miRNA 3'UTR clone - MiUTR3H-05909 from Creative biogene
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FLNB miRNA 3'UTR clone - MiUTR3H-05910 from Creative biogene
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FLNB miRNA 3'UTR clone - MiUTR3H-05911 from Creative biogene
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FLNB miRNA 3'UTR clone - MiUTR3H-05912 from Creative biogene
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