| Gene Symbol |
NUB1
|
| Entrez Gene |
51667
|
| Alt Symbol |
BS4, NUB1L, NYREN18
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
negative regulator of ubiquitin-like proteins 1
|
| Other Description |
NEDD8 ultimate buster 1|NEDD8 ultimate buster-1|renal carcinoma antigen NY-REN-18
|
| Swissprots |
Q8IX22 Q75MR9 O95422 Q9BXR2 Q9Y5A7
|
| Accessions |
AAC82474 AAS02030 EAL24511 EAW54000 EAW54001 EAW54002 EAW54003 Q9Y5A7 AF155099 AAD42865 AF300717 AAK21001 AF459743 AAO14547 AK026433 AK293159 BAH11464 AW205479 AY129295 AAN01355 BC034716 BC046354 AAH46354 BG105733 CN258712 DB048887 XM_005250011 XP_005250068 XM_011516302 XP_011514604 XM_011516303 XP_011514605 XM_011516304 XP_011514606 XM_011516305 XP_011514607 NM_001243351 NP_001230280 NM_016118 NP_057202
|
| Function |
Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2. {ECO:0000269|PubMed:16707496}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11259415}. Note=Predominantly nuclear.
|
| Tissue Specificity |
Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2.
|