Gene Symbol | NUB1 |
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Entrez Gene | 51667 |
Alt Symbol | BS4, NUB1L, NYREN18 |
Species | Human |
Gene Type | protein-coding |
Description | negative regulator of ubiquitin-like proteins 1 |
Other Description | NEDD8 ultimate buster 1|NEDD8 ultimate buster-1|renal carcinoma antigen NY-REN-18 |
Swissprots | Q8IX22 Q75MR9 O95422 Q9BXR2 Q9Y5A7 |
Accessions | AAC82474 AAS02030 EAL24511 EAW54000 EAW54001 EAW54002 EAW54003 Q9Y5A7 AF155099 AAD42865 AF300717 AAK21001 AF459743 AAO14547 AK026433 AK293159 BAH11464 AW205479 AY129295 AAN01355 BC034716 BC046354 AAH46354 BG105733 CN258712 DB048887 XM_005250011 XP_005250068 XM_011516302 XP_011514604 XM_011516303 XP_011514605 XM_011516304 XP_011514606 XM_011516305 XP_011514607 NM_001243351 NP_001230280 NM_016118 NP_057202 |
Function | Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2. {ECO:0000269|PubMed:16707496}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:11259415}. Note=Predominantly nuclear. |
Tissue Specificity | Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2. |
NUB1 CRISPR/Cas9 KO Plasmid (h) - sc-417483 from Santa Cruz Biotechnology
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NUB1 HDR Plasmid (h) - sc-417483-HDR from Santa Cruz Biotechnology
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NUB1 Double Nickase Plasmid (h) - sc-417483-NIC from Santa Cruz Biotechnology
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NUB1 Double Nickase Plasmid (h2) - sc-417483-NIC-2 from Santa Cruz Biotechnology
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NUB1 CRISPR Activation Plasmid (h) - sc-417483-ACT from Santa Cruz Biotechnology
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NUB1 CRISPR Activation Plasmid (h2) - sc-417483-ACT-2 from Santa Cruz Biotechnology
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NUB1 Lentiviral Activation Particles (h) - sc-417483-LAC from Santa Cruz Biotechnology
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NUB1 Lentiviral Activation Particles (h2) - sc-417483-LAC-2 from Santa Cruz Biotechnology
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NUB1 siRNA (h) - sc-61237 from Santa Cruz Biotechnology
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NUB1 shRNA Plasmid (h) - sc-61237-SH from Santa Cruz Biotechnology
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NUB1 shRNA (h) Lentiviral Particles - sc-61237-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU020291 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15576 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15576 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12570 from Sigma-Aldrich
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NUB1 siRNA (Human) - CRH9892 from Cohesion Biosciences
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shRNA set against Human NUB1 (NM_016118.4) - SHH355876 from Creative biogene
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Human NUB1 siRNA - orb270394 from Biorbyt
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NUB1 shRNA Plasmid (Human) - CHH9892 from Cohesion Biosciences
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NUB1 miRNA 3'UTR clone - MiUTR3H-09629 from Creative biogene
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