| Gene Symbol |
PJA2
|
| Entrez Gene |
9867
|
| Alt Symbol |
Neurodap1, RNF131
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
praja ring finger 2, E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase Praja-2|praja 2, RING-H2 motif containing|praja2|ring finger protein 131
|
| Swissprots |
Q68D49 D3DSZ5 O43164 Q8N1G5 A8K6U4
|
| Accessions |
EAW49050 EAW49051 O43164 AB007898 BAA23710 AK291759 BAF84448 BC030826 AAH30826 BM469517 BM681899 BP301854 BQ228553 CR749579 CAH18371 NM_014819 NP_055634
|
| Function |
Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA- mediated long-term memory processes. {ECO:0000269|PubMed:12036302, ECO:0000269|PubMed:21423175}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:21423175}. Cell membrane {ECO:0000269|PubMed:21423175}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21423175}; Peripheral membrane protein {ECO:0000269|PubMed:21423175}. Golgi apparatus membrane {ECO:0000269|PubMed:21423175}; Peripheral membrane protein {ECO:0000269|PubMed:21423175}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus. Expressed in the postsynaptic density region of synapses (By similarity). Colocalizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane. {ECO:0000250}.
|