TRIM72

Gene Symbol TRIM72
Entrez Gene 493829
Alt Symbol MG53
Species Human
Gene Type protein-coding
Description tripartite motif containing 72, E3 ubiquitin protein ligase
Other Description mitsugumin 53|mitsugumin-53|tripartite motif-containing 72|tripartite motif-containing protein 72
Swissprots Q8NBD9 Q8N4X6 Q6ZMU5
Accessions EAW52145 EAW52146 Q6ZMU5 AK090695 BAC03506 AK131485 BAD18630 BC033211 AAH33211 DA058421 DA821604 NM_001008274 NP_001008275
Function Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane, sarcolemma {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}. Note=Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine. {ECO:0000250}.

TRIM72 CRISPR/Cas9 KO Plasmid (h) - sc-403554 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIM72 HDR Plasmid (h) - sc-403554-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIM72 Double Nickase Plasmid (h) - sc-403554-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIM72 Double Nickase Plasmid (h2) - sc-403554-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIM72 CRISPR Activation Plasmid (h) - sc-403554-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIM72 CRISPR Activation Plasmid (h2) - sc-403554-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIM72 Lentiviral Activation Particles (h) - sc-403554-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIM72 Lentiviral Activation Particles (h2) - sc-403554-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIM72 siRNA (h) - sc-93129 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRIM72 shRNA Plasmid (h) - sc-93129-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRIM72 shRNA (h) Lentiviral Particles - sc-93129-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRIM72 RNAi - H00493829-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN22016 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22016 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04355 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04355

TRIM72 siRNA (Human) - CRJ8356 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TRIM72 - MBS8228218 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TRIM72 CRISPR/Cas9 KO Plasmid (h2) - sc-403554-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIM72 HDR Plasmid (h2) - sc-403554-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human TRIM72 (NM_001008274.3) - SHH435080 from Creative biogene

Category siRNA
Species Reactivities Human

Human TRIM72 siRNA - orb278857 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TRIM72 shRNA Plasmid (Human) - CHJ8356 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TRIM72 miRNA 3'UTR clone - MiUTR4H-TG12689 from Creative biogene

Species Reactivities Human
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