TRIM72

Gene Symbol TRIM72
Entrez Gene 493829
Alt Symbol MG53
Species Human
Gene Type protein-coding
Description tripartite motif containing 72, E3 ubiquitin protein ligase
Other Description mitsugumin 53|mitsugumin-53|tripartite motif-containing 72|tripartite motif-containing protein 72
Swissprots Q8NBD9 Q8N4X6 Q6ZMU5
Accessions EAW52145 EAW52146 Q6ZMU5 AK090695 BAC03506 AK131485 BAD18630 BC033211 AAH33211 DA058421 DA821604 NM_001008274 NP_001008275
Function Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane, sarcolemma {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}. Note=Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine. {ECO:0000250}.

Anti-TRIM72 antibody - ab154238 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TRIM72 antibody (ab154238) at 1/1000 dilution + HCT116 whole cell lysate at 30 µg

Anti-TRIM72 antibody - ab68061 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-TRIM72 antibody (ab68061) at 1/500 dilution + Human liver tissue lysate at 25 µgSecondaryGoat anti-mouse IgG (H&L)-HRP conjugated at 1/2500 dilution

Anti-TRIM72 antibody - C-terminal - ab170540 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-TRIM72 antibody - C-terminal (ab170540) at 1/100 dilution + NCI-H292 cell line lysate at 35 µgdeveloped using the ECL technique

Anti-TRIM72 / MG53 Antibody (aa299-327, APC) - LS-C242168 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM72 / MG53 Antibody (aa299-327, Biotin) - LS-C242170 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM72 / MG53 Antibody (aa299-327, FITC) - LS-C242172 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM72 / MG53 Antibody (aa299-327, PE) - LS-C242177 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM72 / MG53 Antibody (aa299-327, Azide-free, HRP) - LS-C247139 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM72 / MG53 Antibody (aa306-335) - LS-C325968 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM72 / MG53 Antibody (aa288-337) - LS-C101995 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TRIM72 antibody LS-C101995 Western blot of Fetal Muscle lysate.

Anti-TRIM72 / MG53 Antibody (clone 3B5) - LS-C139250 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3B5
Immunoprecipitation of TRIM72 transfected lysate using anti-TRIM72 monoclonal antibody and Protein A Magnetic Bead.

Anti-TRIM72 / MG53 Antibody (aa299-327) - LS-C160212 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TRIM72 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human pancreas tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-TRIM72 / MG53 Antibody (aa108-157) IHC-plus™ - LS-B9730 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TRIM72 / MG53 antibody IHC staining of human lung, macrophages. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B9730 concentration 10 ug/ml.

Anti-TRIM72 / MG53 Antibody (aa61-70) IHC-plus™ - LS-B9224 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-TRIM72 / MG53 antibody IHC staining of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-TRIM72 / MG53 Antibody (aa299-327, AP) - LS-C242169 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

TRIM72 Antibody - NBP1-55029 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRIM72 Antibody - NBP1-86000 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
Western Blot: TRIM72 Antibody [NBP1-86000] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11<br/>Lane 2: Human cell line RT-4<br/>Lane 3: Human cell line U-251MG sp<br/>Lane 4: Human plasma (IgG/HSA depleted)

TRIM72 Antibody - NBP1-52104 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: TRIM72 Antibody [NBP1-52104] - Western blot analysis of TRIM72 in Mouse Heart lysate (35ug protein in RIPA buffer) using NBP1-52104 at 0.01ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

TRIM72 Antibody - H00493829-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

TRIM72 Antibody - NBP2-20725 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRIM72 Antibody (2G1) - H00493829-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2G1
Sandwich ELISA: TRIM72 Antibody (2G1) [H00493829-M01] - Detection limit for recombinant GST tagged TRIM72 is 0.1 ng/ml as a capture antibody.

TRIM72 Antibody (3B5) - H00493829-M05 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3B5
Sandwich ELISA: TRIM72 Antibody (3B5) [H00493829-M05] - Detection limit for recombinant GST tagged TRIM72 is 0.1 ng/ml as a capture antibody.

TRIM72 Antibody - H00493829-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

TRIM72 Antibody - H00493829-D01 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRIM72 Antibody (2B8) - H00493829-M04 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2B8
Western Blot: TRIM72 Antibody (2B8) [H00493829-M04] - Analysis of TRIM72 expression in HepG2.
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